SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9

Angiogenesis, the formation of new blood vessels, is involved in a variety of diseases including the tumor growth. In response to various angiogenic stimulations, a number of proteins on the surface of vascular endothelial cells are activated to coordinate cell proliferation, migration, and spreadin...

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Veröffentlicht in:	Journal of cellular physiology 2019-10, Vol.234 (10), p.17280-17294
Hauptverfasser:	Tanigawa, Kazufumi, Maekawa, Masashi, Kiyoi, Takeshi, Nakayama, Jun, Kitazawa, Riko, Kitazawa, Sohei, Semba, Kentaro, Taguchi, Tomohiko, Akita, Satoshi, Yoshida, Motohira, Ishimaru, Kei, Watanabe, Yuji, Higashiyama, Shigeki
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inducing Agents - metabolism Antiangiogenic agents Antiangiogenics Blood vessels Cancer Cell Membrane - metabolism Cell migration Cell Movement - physiology Cell proliferation Cell Proliferation - physiology Cell spreading Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Depletion Drug development Endothelial cells Gene expression Growth factor receptors Growth factors Human Umbilical Vein Endothelial Cells - metabolism Humans Integrin beta1 - metabolism integrin β1 Integrins Integrins - metabolism Intracellular Levels Localization Membrane trafficking Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Nexin Original Original s Prognosis Protein Transport - physiology Proteins Receptors siRNA sorting nexin 9 Sorting Nexins - metabolism Spreading Tumors Umbilical vein Vascular endothelial growth factor Vascular endothelial growth factor receptors
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