Correlation between the rs7101 and rs1063169 polymorphisms in the FOS noncoding region and susceptibility to and prognosis of colorectal cancer
The FOS gene is located on human chromosome 14q21-31 and encodes the nuclear oncoprotein c-Fos. This study analyzed the correlation between the FOS noncoding region rs7101 and rs1063169 polymorphisms and colorectal cancer susceptibility and prognosis. We analyzed the FOS genotypes in 432 colorectal...
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| Veröffentlicht in: | Medicine (Baltimore) 2019-06, Vol.98 (26), p.e16131-e16131 |
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| creator | Chen, Hongshu Ji, Lijuan Liu, Xiuzhen Zhong, Jihong |
| description | The FOS gene is located on human chromosome 14q21-31 and encodes the nuclear oncoprotein c-Fos. This study analyzed the correlation between the FOS noncoding region rs7101 and rs1063169 polymorphisms and colorectal cancer susceptibility and prognosis.
We analyzed the FOS genotypes in 432 colorectal cancer patients and 315 healthy subjects by PCR/Sanger sequencing. Survival was analyzed by Kaplan-Meier and Cox regression analysis. Western blot was used to detect the expression of c-Fos protein in cancer tissues and adjacent tissues in colorectal cancer patients with different genotypes.
The presence of a T allele at rs7101 and a T allele at rs1063169 in FOS carried a higher risk of colorectal cancer [adjusted odds ratio (OR) = 1.237, 95% confidence interval (95% CI) = 1.131-1.346, P ≤ .001 and adjusted OR = 1.218, 95% CI = 1.111-1.327, P ≤ .001, respectively]. c-Fos protein levels were significantly higher in variant cancer tissues than in normal mucosa tissues (P |
| doi_str_mv | 10.1097/MD.0000000000016131 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6617440</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2251102288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4506-b0a7fed35d96f23dd9aa0b712e14d8e6f5ecf18bc3f376a1477b008867c1a4c13</originalsourceid><addsrcrecordid>eNpdkc9u1DAQxiMEotvCEyAhH7mkeGzHTi5IaEspUqsegLPlOJNdg9cOtrerfQpemWy3lD--2Br_vm9m9FXVK6DnQDv19ubinP45IIHDk2oBDZd100nxtFpQyppadUqcVKc5f5shrph4Xp1wYHIGm0X1cxlTQm-Ki4H0WHaIgZQ1kpQVUCAmDPMTqOQgOzJFv9_ENK1d3mTijuTl7WcSYrBxcGFFEq4OVgdd3maLU3G9867sSYn31SnFVYjZZRJHYqOPCW0xnlgTLKYX1bPR-IwvH-6z6uvlhy_Lq_r69uOn5fvr2oqGyrqnRo048Gbo5Mj4MHTG0F4BQxBDi3Js0I7Q9paPXEkDQqme0raVyoIRFvhZ9e7oO237DQ4WQ0nG6ym5jUl7HY3T__4Et9areKelBCUEnQ3ePBik-GOLueiNm9f13gSM26wZawAoY207o_yI2hRzTjg-tgGqD1Hqmwv9f5Sz6vXfEz5qfmc3A-II7KIvmPJ3v91h0ms0vqzv_RrVsZpR6KhkLa3nipD8F8Hkq2w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2251102288</pqid></control><display><type>article</type><title>Correlation between the rs7101 and rs1063169 polymorphisms in the FOS noncoding region and susceptibility to and prognosis of colorectal cancer</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wolters Kluwer Open Health</source><source>IngentaConnect Free/Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Chen, Hongshu ; Ji, Lijuan ; Liu, Xiuzhen ; Zhong, Jihong</creator><creatorcontrib>Chen, Hongshu ; Ji, Lijuan ; Liu, Xiuzhen ; Zhong, Jihong</creatorcontrib><description>The FOS gene is located on human chromosome 14q21-31 and encodes the nuclear oncoprotein c-Fos. This study analyzed the correlation between the FOS noncoding region rs7101 and rs1063169 polymorphisms and colorectal cancer susceptibility and prognosis.
We analyzed the FOS genotypes in 432 colorectal cancer patients and 315 healthy subjects by PCR/Sanger sequencing. Survival was analyzed by Kaplan-Meier and Cox regression analysis. Western blot was used to detect the expression of c-Fos protein in cancer tissues and adjacent tissues in colorectal cancer patients with different genotypes.
The presence of a T allele at rs7101 and a T allele at rs1063169 in FOS carried a higher risk of colorectal cancer [adjusted odds ratio (OR) = 1.237, 95% confidence interval (95% CI) = 1.131-1.346, P ≤ .001 and adjusted OR = 1.218, 95% CI = 1.111-1.327, P ≤ .001, respectively]. c-Fos protein levels were significantly higher in variant cancer tissues than in normal mucosa tissues (P < .05), and c-Fos proteins levels were also higher in homozygous variant cancer tissues than in heterozygous variant cancer tissues. The 3-year survival rate of patients with wild-type FOS was higher than that of patients with variant FOS (P < .05).
The rs7101 and rs1063169 polymorphisms in the noncoding region of FOS are associated with the risk of developing colorectal cancer and the progression of colorectal cancer, which may be because the mutation enhances the expression of c-Fos protein to promote the incidence and development of colorectal cancer.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000016131</identifier><identifier>PMID: 31261535</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Clinical Trial/Experimental Study ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Disease Progression ; Female ; Follow-Up Studies ; Gene Expression ; Gene-Environment Interaction ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; Male ; Middle Aged ; Neoplasm Staging ; Polymorphism, Single Nucleotide ; Prognosis ; Proto-Oncogene Proteins c-fos - genetics ; Proto-Oncogene Proteins c-fos - metabolism ; Survival Analysis</subject><ispartof>Medicine (Baltimore), 2019-06, Vol.98 (26), p.e16131-e16131</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4506-b0a7fed35d96f23dd9aa0b712e14d8e6f5ecf18bc3f376a1477b008867c1a4c13</citedby><cites>FETCH-LOGICAL-c4506-b0a7fed35d96f23dd9aa0b712e14d8e6f5ecf18bc3f376a1477b008867c1a4c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617440/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617440/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31261535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hongshu</creatorcontrib><creatorcontrib>Ji, Lijuan</creatorcontrib><creatorcontrib>Liu, Xiuzhen</creatorcontrib><creatorcontrib>Zhong, Jihong</creatorcontrib><title>Correlation between the rs7101 and rs1063169 polymorphisms in the FOS noncoding region and susceptibility to and prognosis of colorectal cancer</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The FOS gene is located on human chromosome 14q21-31 and encodes the nuclear oncoprotein c-Fos. This study analyzed the correlation between the FOS noncoding region rs7101 and rs1063169 polymorphisms and colorectal cancer susceptibility and prognosis.
We analyzed the FOS genotypes in 432 colorectal cancer patients and 315 healthy subjects by PCR/Sanger sequencing. Survival was analyzed by Kaplan-Meier and Cox regression analysis. Western blot was used to detect the expression of c-Fos protein in cancer tissues and adjacent tissues in colorectal cancer patients with different genotypes.
The presence of a T allele at rs7101 and a T allele at rs1063169 in FOS carried a higher risk of colorectal cancer [adjusted odds ratio (OR) = 1.237, 95% confidence interval (95% CI) = 1.131-1.346, P ≤ .001 and adjusted OR = 1.218, 95% CI = 1.111-1.327, P ≤ .001, respectively]. c-Fos protein levels were significantly higher in variant cancer tissues than in normal mucosa tissues (P < .05), and c-Fos proteins levels were also higher in homozygous variant cancer tissues than in heterozygous variant cancer tissues. The 3-year survival rate of patients with wild-type FOS was higher than that of patients with variant FOS (P < .05).
The rs7101 and rs1063169 polymorphisms in the noncoding region of FOS are associated with the risk of developing colorectal cancer and the progression of colorectal cancer, which may be because the mutation enhances the expression of c-Fos protein to promote the incidence and development of colorectal cancer.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Clinical Trial/Experimental Study</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Expression</subject><subject>Gene-Environment Interaction</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Survival Analysis</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9u1DAQxiMEotvCEyAhH7mkeGzHTi5IaEspUqsegLPlOJNdg9cOtrerfQpemWy3lD--2Br_vm9m9FXVK6DnQDv19ubinP45IIHDk2oBDZd100nxtFpQyppadUqcVKc5f5shrph4Xp1wYHIGm0X1cxlTQm-Ki4H0WHaIgZQ1kpQVUCAmDPMTqOQgOzJFv9_ENK1d3mTijuTl7WcSYrBxcGFFEq4OVgdd3maLU3G9867sSYn31SnFVYjZZRJHYqOPCW0xnlgTLKYX1bPR-IwvH-6z6uvlhy_Lq_r69uOn5fvr2oqGyrqnRo048Gbo5Mj4MHTG0F4BQxBDi3Js0I7Q9paPXEkDQqme0raVyoIRFvhZ9e7oO237DQ4WQ0nG6ym5jUl7HY3T__4Et9areKelBCUEnQ3ePBik-GOLueiNm9f13gSM26wZawAoY207o_yI2hRzTjg-tgGqD1Hqmwv9f5Sz6vXfEz5qfmc3A-II7KIvmPJ3v91h0ms0vqzv_RrVsZpR6KhkLa3nipD8F8Hkq2w</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Chen, Hongshu</creator><creator>Ji, Lijuan</creator><creator>Liu, Xiuzhen</creator><creator>Zhong, Jihong</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190601</creationdate><title>Correlation between the rs7101 and rs1063169 polymorphisms in the FOS noncoding region and susceptibility to and prognosis of colorectal cancer</title><author>Chen, Hongshu ; Ji, Lijuan ; Liu, Xiuzhen ; Zhong, Jihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4506-b0a7fed35d96f23dd9aa0b712e14d8e6f5ecf18bc3f376a1477b008867c1a4c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Clinical Trial/Experimental Study</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Expression</topic><topic>Gene-Environment Interaction</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hongshu</creatorcontrib><creatorcontrib>Ji, Lijuan</creatorcontrib><creatorcontrib>Liu, Xiuzhen</creatorcontrib><creatorcontrib>Zhong, Jihong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hongshu</au><au>Ji, Lijuan</au><au>Liu, Xiuzhen</au><au>Zhong, Jihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between the rs7101 and rs1063169 polymorphisms in the FOS noncoding region and susceptibility to and prognosis of colorectal cancer</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>98</volume><issue>26</issue><spage>e16131</spage><epage>e16131</epage><pages>e16131-e16131</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The FOS gene is located on human chromosome 14q21-31 and encodes the nuclear oncoprotein c-Fos. This study analyzed the correlation between the FOS noncoding region rs7101 and rs1063169 polymorphisms and colorectal cancer susceptibility and prognosis.
We analyzed the FOS genotypes in 432 colorectal cancer patients and 315 healthy subjects by PCR/Sanger sequencing. Survival was analyzed by Kaplan-Meier and Cox regression analysis. Western blot was used to detect the expression of c-Fos protein in cancer tissues and adjacent tissues in colorectal cancer patients with different genotypes.
The presence of a T allele at rs7101 and a T allele at rs1063169 in FOS carried a higher risk of colorectal cancer [adjusted odds ratio (OR) = 1.237, 95% confidence interval (95% CI) = 1.131-1.346, P ≤ .001 and adjusted OR = 1.218, 95% CI = 1.111-1.327, P ≤ .001, respectively]. c-Fos protein levels were significantly higher in variant cancer tissues than in normal mucosa tissues (P < .05), and c-Fos proteins levels were also higher in homozygous variant cancer tissues than in heterozygous variant cancer tissues. The 3-year survival rate of patients with wild-type FOS was higher than that of patients with variant FOS (P < .05).
The rs7101 and rs1063169 polymorphisms in the noncoding region of FOS are associated with the risk of developing colorectal cancer and the progression of colorectal cancer, which may be because the mutation enhances the expression of c-Fos protein to promote the incidence and development of colorectal cancer.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>31261535</pmid><doi>10.1097/MD.0000000000016131</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Clinical Trial/Experimental Study Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease Progression Female Follow-Up Studies Gene Expression Gene-Environment Interaction Genetic Association Studies Genetic Predisposition to Disease Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Middle Aged Neoplasm Staging Polymorphism, Single Nucleotide Prognosis Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Survival Analysis |
| title | Correlation between the rs7101 and rs1063169 polymorphisms in the FOS noncoding region and susceptibility to and prognosis of colorectal cancer |
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