Better prediction for FGR (fetal growth restriction) with the sFlt-1/PIGF ratio: A case-control study
The aim of this study was to check whether the sFlt-1/PIGF ratio, established as the biomarker for preeclampsia, reduces the false positive rate of late fetal growth restriction (FGR) detection by ultrasound biometry.This was a prospective case-control study, conducted at one regional maternity hosp...
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| Veröffentlicht in: | Medicine (Baltimore) 2019-06, Vol.98 (26), p.e16069-e16069 |
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| creator | Visan, Valeria Scripcariu, Ioana Sadiye Socolov, Demetra Costescu, Amelia Rusu, Daniela Socolov, Razvan Avasiloaiei, Andreea Boiculese, Lucian Dimitriu, Cristina |
| description | The aim of this study was to check whether the sFlt-1/PIGF ratio, established as the biomarker for preeclampsia, reduces the false positive rate of late fetal growth restriction (FGR) detection by ultrasound biometry.This was a prospective case-control study, conducted at one regional maternity hospital in Romania. Study participants included singleton pregnancy women for whom the estimated fetal weight (EFW) at 28 to 35 weeks was 10 percentiles. All pregnancies were dated in the first trimester by crown-rump-length. We also recorded maternal characteristics, pregnancy and neonatal outcomes.The primary outcome measures were the relation between the sFlt-1/PIGF ratio and incidence of FGR. Secondary outcome was establishing a threshold for statistical significance of the marker and influence of other conditions (e.g., pre-eclampsia) on the accuracy of the marker in FGR prediction.Included in the study were 37 pregnant women and 37 controls.When we used ultrasound (US) biometry and maternal risk factors to estimate EFW |
| doi_str_mv | 10.1097/MD.0000000000016069 |
| format | Article |
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Study participants included singleton pregnancy women for whom the estimated fetal weight (EFW) at 28 to 35 weeks was < 10 percentiles and as controls, pregnant women with EFW >10 percentiles. All pregnancies were dated in the first trimester by crown-rump-length. We also recorded maternal characteristics, pregnancy and neonatal outcomes.The primary outcome measures were the relation between the sFlt-1/PIGF ratio and incidence of FGR. Secondary outcome was establishing a threshold for statistical significance of the marker and influence of other conditions (e.g., pre-eclampsia) on the accuracy of the marker in FGR prediction.Included in the study were 37 pregnant women and 37 controls.When we used ultrasound (US) biometry and maternal risk factors to estimate EFW <10 percentiles, the sensitivity was 44.4% with a specificity of 89% for an FPR (false positive result) of 10%. When we combined the US biometry and maternal risk factors with sFlt1/PIGF ratio, for a cut off of 38, the sensitivity was 84.21%, and the specificity was 84.31% for an FPR of 10%. The cut off value (36) did not change if we considered all cases of SGA, including those with associated preeclampsia or if we considered only FGR cases without associated preeclampsia.When associated with maternal factors and US biometry, the sFlt1/PIGF ratio enhanced the sensitivity for detecting late FGR.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000016069</identifier><identifier>PMID: 31261515</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Adult ; Biomarkers - blood ; Biometry ; Case-Control Studies ; False Positive Reactions ; Female ; Fetal Growth Retardation - diagnosis ; Fetal Growth Retardation - epidemiology ; Humans ; Incidence ; Observational Study ; Placenta Growth Factor - blood ; Pregnancy ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Prospective Studies ; Risk Factors ; Sensitivity and Specificity ; Ultrasonography, Prenatal ; Vascular Endothelial Growth Factor Receptor-1 - blood ; Young Adult</subject><ispartof>Medicine (Baltimore), 2019-06, Vol.98 (26), p.e16069-e16069</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3556-222d9a164656698f1e1e8745655c3df1b71cd0cdd486eb798a0a12783543e6e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616245/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616245/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31261515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Visan, Valeria</creatorcontrib><creatorcontrib>Scripcariu, Ioana Sadiye</creatorcontrib><creatorcontrib>Socolov, Demetra</creatorcontrib><creatorcontrib>Costescu, Amelia</creatorcontrib><creatorcontrib>Rusu, Daniela</creatorcontrib><creatorcontrib>Socolov, Razvan</creatorcontrib><creatorcontrib>Avasiloaiei, Andreea</creatorcontrib><creatorcontrib>Boiculese, Lucian</creatorcontrib><creatorcontrib>Dimitriu, Cristina</creatorcontrib><title>Better prediction for FGR (fetal growth restriction) with the sFlt-1/PIGF ratio: A case-control study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The aim of this study was to check whether the sFlt-1/PIGF ratio, established as the biomarker for preeclampsia, reduces the false positive rate of late fetal growth restriction (FGR) detection by ultrasound biometry.This was a prospective case-control study, conducted at one regional maternity hospital in Romania. Study participants included singleton pregnancy women for whom the estimated fetal weight (EFW) at 28 to 35 weeks was < 10 percentiles and as controls, pregnant women with EFW >10 percentiles. All pregnancies were dated in the first trimester by crown-rump-length. We also recorded maternal characteristics, pregnancy and neonatal outcomes.The primary outcome measures were the relation between the sFlt-1/PIGF ratio and incidence of FGR. Secondary outcome was establishing a threshold for statistical significance of the marker and influence of other conditions (e.g., pre-eclampsia) on the accuracy of the marker in FGR prediction.Included in the study were 37 pregnant women and 37 controls.When we used ultrasound (US) biometry and maternal risk factors to estimate EFW <10 percentiles, the sensitivity was 44.4% with a specificity of 89% for an FPR (false positive result) of 10%. When we combined the US biometry and maternal risk factors with sFlt1/PIGF ratio, for a cut off of 38, the sensitivity was 84.21%, and the specificity was 84.31% for an FPR of 10%. The cut off value (36) did not change if we considered all cases of SGA, including those with associated preeclampsia or if we considered only FGR cases without associated preeclampsia.When associated with maternal factors and US biometry, the sFlt1/PIGF ratio enhanced the sensitivity for detecting late FGR.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Biometry</subject><subject>Case-Control Studies</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Fetal Growth Retardation - diagnosis</subject><subject>Fetal Growth Retardation - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Observational Study</subject><subject>Placenta Growth Factor - blood</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy Trimester, Third</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography, Prenatal</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - blood</subject><subject>Young Adult</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1vFDEMhiMEotvCL0BCOZbDtHEyyUw4IJWWXSq1oqrgHGUzns5AdrMkGVb99w3dtnz4Ysl-_NrWS8gbYEfAdHN8eXbE_gQopvQzMgMpVCW1qp-TGWNcVo1u6j2yn9L3AomG1y_JngCuQIKcEfyIOWOkm4jd6PIY1rQPkc4X1_Swx2w9vYlhmwcaMeW4I97R7VgqeUCa5j5XcHx1vpjTaEvzPT2hziasXFjnGDxNeepuX5EXvfUJXz_kA_Jt_unr6efq4svi_PTkonJCSlVxzjttQdVKKqXbHhCwbWqppHSi62HZgOuY67q6VbhsdGuZBd60QtYCFWpxQD7sdDfTcoWdw3KD9WYTx5WNtybY0fzbWY-DuQm_jFKgeC2LwOGDQAw_p_KyWY3Jofd2jWFKhnMJwEBqXlCxQ10MKUXsn9YAM78NMpdn5n-DytTbvy98mnl0pAD1DtgGX4xJP_y0xWgGtD4P93qy0bziDDRTvGVVqXAl7gDsZ5pX</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Visan, Valeria</creator><creator>Scripcariu, Ioana Sadiye</creator><creator>Socolov, Demetra</creator><creator>Costescu, Amelia</creator><creator>Rusu, Daniela</creator><creator>Socolov, Razvan</creator><creator>Avasiloaiei, Andreea</creator><creator>Boiculese, Lucian</creator><creator>Dimitriu, Cristina</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190601</creationdate><title>Better prediction for FGR (fetal growth restriction) with the sFlt-1/PIGF ratio: A case-control study</title><author>Visan, Valeria ; Scripcariu, Ioana Sadiye ; Socolov, Demetra ; Costescu, Amelia ; Rusu, Daniela ; Socolov, Razvan ; Avasiloaiei, Andreea ; Boiculese, Lucian ; Dimitriu, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3556-222d9a164656698f1e1e8745655c3df1b71cd0cdd486eb798a0a12783543e6e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Biometry</topic><topic>Case-Control Studies</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Fetal Growth Retardation - diagnosis</topic><topic>Fetal Growth Retardation - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Observational Study</topic><topic>Placenta Growth Factor - blood</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy Trimester, Third</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography, Prenatal</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visan, Valeria</creatorcontrib><creatorcontrib>Scripcariu, Ioana Sadiye</creatorcontrib><creatorcontrib>Socolov, Demetra</creatorcontrib><creatorcontrib>Costescu, Amelia</creatorcontrib><creatorcontrib>Rusu, Daniela</creatorcontrib><creatorcontrib>Socolov, Razvan</creatorcontrib><creatorcontrib>Avasiloaiei, Andreea</creatorcontrib><creatorcontrib>Boiculese, Lucian</creatorcontrib><creatorcontrib>Dimitriu, Cristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visan, Valeria</au><au>Scripcariu, Ioana Sadiye</au><au>Socolov, Demetra</au><au>Costescu, Amelia</au><au>Rusu, Daniela</au><au>Socolov, Razvan</au><au>Avasiloaiei, Andreea</au><au>Boiculese, Lucian</au><au>Dimitriu, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Better prediction for FGR (fetal growth restriction) with the sFlt-1/PIGF ratio: A case-control study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>98</volume><issue>26</issue><spage>e16069</spage><epage>e16069</epage><pages>e16069-e16069</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The aim of this study was to check whether the sFlt-1/PIGF ratio, established as the biomarker for preeclampsia, reduces the false positive rate of late fetal growth restriction (FGR) detection by ultrasound biometry.This was a prospective case-control study, conducted at one regional maternity hospital in Romania. Study participants included singleton pregnancy women for whom the estimated fetal weight (EFW) at 28 to 35 weeks was < 10 percentiles and as controls, pregnant women with EFW >10 percentiles. All pregnancies were dated in the first trimester by crown-rump-length. We also recorded maternal characteristics, pregnancy and neonatal outcomes.The primary outcome measures were the relation between the sFlt-1/PIGF ratio and incidence of FGR. Secondary outcome was establishing a threshold for statistical significance of the marker and influence of other conditions (e.g., pre-eclampsia) on the accuracy of the marker in FGR prediction.Included in the study were 37 pregnant women and 37 controls.When we used ultrasound (US) biometry and maternal risk factors to estimate EFW <10 percentiles, the sensitivity was 44.4% with a specificity of 89% for an FPR (false positive result) of 10%. When we combined the US biometry and maternal risk factors with sFlt1/PIGF ratio, for a cut off of 38, the sensitivity was 84.21%, and the specificity was 84.31% for an FPR of 10%. The cut off value (36) did not change if we considered all cases of SGA, including those with associated preeclampsia or if we considered only FGR cases without associated preeclampsia.When associated with maternal factors and US biometry, the sFlt1/PIGF ratio enhanced the sensitivity for detecting late FGR.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>31261515</pmid><doi>10.1097/MD.0000000000016069</doi><oa>free_for_read</oa></addata></record> |
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| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Biomarkers - blood Biometry Case-Control Studies False Positive Reactions Female Fetal Growth Retardation - diagnosis Fetal Growth Retardation - epidemiology Humans Incidence Observational Study Placenta Growth Factor - blood Pregnancy Pregnancy Trimester, Second Pregnancy Trimester, Third Prospective Studies Risk Factors Sensitivity and Specificity Ultrasonography, Prenatal Vascular Endothelial Growth Factor Receptor-1 - blood Young Adult |
| title | Better prediction for FGR (fetal growth restriction) with the sFlt-1/PIGF ratio: A case-control study |
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