PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines

Pancreatic ductal adenocarcinoma (PDA) remains the most lethal malignancy due to lack of an effective treatment. P21-activated kinases (PAKs) play a key role not only in cell proliferation and migration, but also in mediating chemo-resistance in PDA. The aim of this study was to investigate the comb...

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Veröffentlicht in:	American journal of translational research 2019-01, Vol.11 (6), p.3353-3364
Hauptverfasser:	Wang, Kai, Huynh, Nhi, Wang, Xiao, Pajic, Marina, Parkin, Ashleigh, Man, Jennifer, Baldwin, Graham S, Nikfarjam, Mehrdad, He, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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