Translation control of the immune checkpoint in cancer and its therapeutic targeting

Cancer cells develop mechanisms to escape immunosurveillance, among which modulating the expression of immune suppressive messenger RNAs is most well-documented. However, how this is molecularly achieved remains largely unresolved. Here, we develop an in vivo mouse model of liver cancer to study onc...

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Veröffentlicht in:	Nature medicine 2019-02, Vol.25 (2), p.301-311
Hauptverfasser:	Xu, Yichen, Poggio, Mauro, Jin, Hyun Yong, Shi, Zhen, Forester, Craig M., Wang, Ying, Stumpf, Craig R., Xue, Lingru, Devericks, Emily, So, Lomon, Nguyen, Hao G., Griselin, Alice, Gordan, John D., Umetsu, Sarah E, Reich, Siegfried H., Worland, Stephen T., Asthana, Saurabh, Barna, Maria, Webster, Kevin R., Cunningham, John T., Ruggero, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Animals B7-H1 Antigen - metabolism Base Sequence Biomedical and Life Sciences Biomedicine Cancer Cancer cells Cancer genetics Cancer metastasis Cancer Research Care and treatment Death Development and progression Disease Progression Down-Regulation Eukaryotic Initiation Factor-4E - metabolism Footprinting Gene Expression Regulation, Neoplastic Genetic aspects Genomes Genomics Health aspects Immune checkpoint Immune Evasion Immune system Immunosurveillance Immunotherapy In vivo methods and tests Infectious Diseases Initiation factor eIF-4E Kaplan-Meier Estimate Laboratory rats Liver Liver cancer Liver Neoplasms - genetics Liver Neoplasms - immunology Liver Neoplasms - pathology Liver Neoplasms - therapy Medical schools Messenger RNA Metabolic Diseases Metastases Mice, Inbred C57BL Molecular Medicine mRNA Myc protein Neoplasm Metastasis Neurosciences Open reading frames Open Reading Frames - genetics PD-L1 protein Phosphorylation Protein Biosynthesis Proteins Proto-Oncogene Proteins c-myc - metabolism Proto-Oncogene Proteins p21(ras) - metabolism Pyridines - pharmacology Pyrimidines - pharmacology Reorganization and restructuring RNA Therapeutic targets Transcription, Genetic Translation (Genetics) Tumor Microenvironment Tumors Up-Regulation - genetics
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