Sex, Age, and BMI Modulate the Association of Physical Examinations and Blood Biochemistry Parameters and NAFLD: A Retrospective Study on 1994 Cases Observed at Shuguang Hospital, China

Objective. Previous studies have shown that some metabolic risk factors are related to nonalcoholic fatty liver disease (NAFLD). This retrospective study was performed to investigate the associations between physical examinations and blood biochemistry parameters and NAFLD status and to identify pos...

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Veröffentlicht in:BioMed research international 2019-01, Vol.2019 (2019), p.1-7
Hauptverfasser: Cheng, Feng, Wang, Yi-Qin, Fan, Lin, Jean-Baptiste, Lori, Patel, Devashru, Wang, Fang, Hao, Yiming, Pham, Minh, Tang, Zhengli, Wang, Weijian
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container_issue 2019
container_start_page 1
container_title BioMed research international
container_volume 2019
creator Cheng, Feng
Wang, Yi-Qin
Fan, Lin
Jean-Baptiste, Lori
Patel, Devashru
Wang, Fang
Hao, Yiming
Pham, Minh
Tang, Zhengli
Wang, Weijian
description Objective. Previous studies have shown that some metabolic risk factors are related to nonalcoholic fatty liver disease (NAFLD). This retrospective study was performed to investigate the associations between physical examinations and blood biochemistry parameters and NAFLD status and to identify possible risk factors of NAFLD. Methods. Study participants underwent general physical examinations, blood biochemistry, and abdominal ultrasound evaluations. In addition, data regarding sex, age, ethnicity, medical history, and alcohol consumption of participants were recorded. Among the study participants (N=1994), 57.8% were male, 41.2% over the age of 50, and 52.6% with BMI≥24. 986 patients had NAFLD and 1008 had no NAFLD. We used effect size analysis and logistic regression to determine which physical examinations and blood biochemistry parameters were significant for the association between these parameters and NAFLD status. Results. Both the effect size and logistic regression indicated that BMI, diastolic blood pressure (DBP), triglycerides (TG), and serum uric acid (SUA) show a significant association with NAFLD. Females are overall at a higher risk of NAFLD, but factors such as high BMI, DBP, TG, and SUA increase the associated risk for both sexes. Compared with males, females have a higher risk of NAFLD given that they are over 50, overweight and obese (BMI at or over 24), or have high SUA. In terms of age, people older than 50 with high SUA, and people younger than 50 with high DBP and low-density lipoprotein cholesterol (LDL-C) all increase the risk of NAFLD. For BMI, high DBP and low high-density lipoprotein cholesterol (HDL-C) are risk factors for NAFLD in overweight and obese people (BMI at or over 24), whereas in normal weight and underweight people (BMI under 24), elevated LDL-C increases the risk of NAFLD. Conclusions. Our results revealed sex, age, and BMI modulate the association of physical examinations and blood biochemistry parameters and NAFLD, which may facilitate the development of personalized early warning and prevention strategies of NAFLD for at-risk populations.
doi_str_mv 10.1155/2019/1246518
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Previous studies have shown that some metabolic risk factors are related to nonalcoholic fatty liver disease (NAFLD). This retrospective study was performed to investigate the associations between physical examinations and blood biochemistry parameters and NAFLD status and to identify possible risk factors of NAFLD. Methods. Study participants underwent general physical examinations, blood biochemistry, and abdominal ultrasound evaluations. In addition, data regarding sex, age, ethnicity, medical history, and alcohol consumption of participants were recorded. Among the study participants (N=1994), 57.8% were male, 41.2% over the age of 50, and 52.6% with BMI≥24. 986 patients had NAFLD and 1008 had no NAFLD. We used effect size analysis and logistic regression to determine which physical examinations and blood biochemistry parameters were significant for the association between these parameters and NAFLD status. Results. Both the effect size and logistic regression indicated that BMI, diastolic blood pressure (DBP), triglycerides (TG), and serum uric acid (SUA) show a significant association with NAFLD. Females are overall at a higher risk of NAFLD, but factors such as high BMI, DBP, TG, and SUA increase the associated risk for both sexes. Compared with males, females have a higher risk of NAFLD given that they are over 50, overweight and obese (BMI at or over 24), or have high SUA. In terms of age, people older than 50 with high SUA, and people younger than 50 with high DBP and low-density lipoprotein cholesterol (LDL-C) all increase the risk of NAFLD. For BMI, high DBP and low high-density lipoprotein cholesterol (HDL-C) are risk factors for NAFLD in overweight and obese people (BMI at or over 24), whereas in normal weight and underweight people (BMI under 24), elevated LDL-C increases the risk of NAFLD. Conclusions. Our results revealed sex, age, and BMI modulate the association of physical examinations and blood biochemistry parameters and NAFLD, which may facilitate the development of personalized early warning and prevention strategies of NAFLD for at-risk populations.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/1246518</identifier><identifier>PMID: 31341886</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Abdomen ; Adult ; Age ; Alcohol ; Alcoholic beverages ; Biochemistry ; Blood pressure ; Body mass ; Body Mass Index ; Body weight ; China ; Chinese medicine ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Density ; Family medical history ; Fatty liver ; Female ; Females ; Gastroenterology ; Gastrointestinal surgery ; Hepatitis ; Hepatology ; High density lipoprotein ; Hospitals ; Humans ; Identification methods ; Liver ; Liver diseases ; Low density lipoprotein ; Low density lipoproteins ; Male ; Males ; Medical research ; Medicine, Experimental ; Metabolism ; Middle Aged ; Minority &amp; ethnic groups ; Non-alcoholic Fatty Liver Disease - blood ; Non-alcoholic Fatty Liver Disease - diagnostic imaging ; Obesity ; Obesity - blood ; Obesity - diagnostic imaging ; Overweight ; Parameter identification ; Periodic health examinations ; Physical diagnosis ; Physical examinations ; Prospective Studies ; Regression analysis ; Retrospective Studies ; Risk analysis ; Risk Factors ; Sex ; Studies ; Systematic review ; Triglycerides ; Ultrasonic imaging ; Ultrasound ; Underweight ; Uric acid</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-7</ispartof><rights>Copyright © 2019 Zhengli Tang et al.</rights><rights>COPYRIGHT 2019 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2019 Zhengli Tang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Zhengli Tang et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-cbe002ebec09944c47a678efa5edcfe39459eae929f5d3a10439dcfa900856563</citedby><cites>FETCH-LOGICAL-c499t-cbe002ebec09944c47a678efa5edcfe39459eae929f5d3a10439dcfa900856563</cites><orcidid>0000-0001-6197-8836 ; 0000-0001-9374-2369 ; 0000-0003-3619-8090 ; 0000-0002-0280-7495 ; 0000-0001-7574-9401</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612989/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612989/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31341886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Grasselli, Elena</contributor><creatorcontrib>Cheng, Feng</creatorcontrib><creatorcontrib>Wang, Yi-Qin</creatorcontrib><creatorcontrib>Fan, Lin</creatorcontrib><creatorcontrib>Jean-Baptiste, Lori</creatorcontrib><creatorcontrib>Patel, Devashru</creatorcontrib><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Hao, Yiming</creatorcontrib><creatorcontrib>Pham, Minh</creatorcontrib><creatorcontrib>Tang, Zhengli</creatorcontrib><creatorcontrib>Wang, Weijian</creatorcontrib><title>Sex, Age, and BMI Modulate the Association of Physical Examinations and Blood Biochemistry Parameters and NAFLD: A Retrospective Study on 1994 Cases Observed at Shuguang Hospital, China</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Objective. Previous studies have shown that some metabolic risk factors are related to nonalcoholic fatty liver disease (NAFLD). This retrospective study was performed to investigate the associations between physical examinations and blood biochemistry parameters and NAFLD status and to identify possible risk factors of NAFLD. Methods. Study participants underwent general physical examinations, blood biochemistry, and abdominal ultrasound evaluations. In addition, data regarding sex, age, ethnicity, medical history, and alcohol consumption of participants were recorded. Among the study participants (N=1994), 57.8% were male, 41.2% over the age of 50, and 52.6% with BMI≥24. 986 patients had NAFLD and 1008 had no NAFLD. We used effect size analysis and logistic regression to determine which physical examinations and blood biochemistry parameters were significant for the association between these parameters and NAFLD status. Results. Both the effect size and logistic regression indicated that BMI, diastolic blood pressure (DBP), triglycerides (TG), and serum uric acid (SUA) show a significant association with NAFLD. Females are overall at a higher risk of NAFLD, but factors such as high BMI, DBP, TG, and SUA increase the associated risk for both sexes. Compared with males, females have a higher risk of NAFLD given that they are over 50, overweight and obese (BMI at or over 24), or have high SUA. In terms of age, people older than 50 with high SUA, and people younger than 50 with high DBP and low-density lipoprotein cholesterol (LDL-C) all increase the risk of NAFLD. For BMI, high DBP and low high-density lipoprotein cholesterol (HDL-C) are risk factors for NAFLD in overweight and obese people (BMI at or over 24), whereas in normal weight and underweight people (BMI under 24), elevated LDL-C increases the risk of NAFLD. Conclusions. Our results revealed sex, age, and BMI modulate the association of physical examinations and blood biochemistry parameters and NAFLD, which may facilitate the development of personalized early warning and prevention strategies of NAFLD for at-risk populations.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Age</subject><subject>Alcohol</subject><subject>Alcoholic beverages</subject><subject>Biochemistry</subject><subject>Blood pressure</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>China</subject><subject>Chinese medicine</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Density</subject><subject>Family medical history</subject><subject>Fatty liver</subject><subject>Female</subject><subject>Females</subject><subject>Gastroenterology</subject><subject>Gastrointestinal surgery</subject><subject>Hepatitis</subject><subject>Hepatology</subject><subject>High density lipoprotein</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Identification methods</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Males</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Minority &amp; ethnic groups</subject><subject>Non-alcoholic Fatty Liver Disease - blood</subject><subject>Non-alcoholic Fatty Liver Disease - diagnostic imaging</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - diagnostic imaging</subject><subject>Overweight</subject><subject>Parameter identification</subject><subject>Periodic health examinations</subject><subject>Physical diagnosis</subject><subject>Physical examinations</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Sex</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Triglycerides</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Underweight</subject><subject>Uric acid</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNklFv0zAQxyMEYtPYG8_IEi9ItMyOHTfmASmUjU3q2ETh2XKdS-MpjUvslPWj8e24ktIBT_jBtny_-5_vr0uS54y-YSzLzlLK1BlLhcxY_ig5TjkTY8kEe3y4c36UnIZwR3HlTFIlnyZHnHHB8lweJz_mcD8ixRJGxLQleX99Ra592TcmAok1kCIEb52JzrfEV-S23gZnTUPO783Ktb_ew5DZeI-787aGlQux25Jb05kVROgG4lNxMfvwlhTkM8TOhzXY6DZA5rEvtwTlmVKCTE2AQG4WAboNlMREMq_7ZW_aJbnEHBdNMyLTGks_S55Upglwuj9Pkq8X51-ml-PZzceraTEbW6FUHNsFUJrCAixFfWHFxMhJDpXJoLQVcCUyBQZUqqqs5IZRwRUGjEK7MplJfpK8G3TX_WKFOdDGzjR63bmV6bbaG6f_jrSu1ku_0VKyVOUKBV7tBTr_rYcQNfpjoWlMC74POk1lNskFTwWiL_9B73zftdgeUhmniks1eaCWpgHt2spjXbsT1YWkXFCOVZEaDZRFs0MH1eHLjOrd8Ojd8Oj98CD-4s82D_DvUUHg9QCg-aX57v5TDpBBtx9olvIUgZ9rStV8</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Cheng, Feng</creator><creator>Wang, Yi-Qin</creator><creator>Fan, Lin</creator><creator>Jean-Baptiste, Lori</creator><creator>Patel, Devashru</creator><creator>Wang, Fang</creator><creator>Hao, Yiming</creator><creator>Pham, Minh</creator><creator>Tang, Zhengli</creator><creator>Wang, Weijian</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; 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Wang, Yi-Qin ; Fan, Lin ; Jean-Baptiste, Lori ; Patel, Devashru ; Wang, Fang ; Hao, Yiming ; Pham, Minh ; Tang, Zhengli ; Wang, Weijian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-cbe002ebec09944c47a678efa5edcfe39459eae929f5d3a10439dcfa900856563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Age</topic><topic>Alcohol</topic><topic>Alcoholic beverages</topic><topic>Biochemistry</topic><topic>Blood pressure</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>China</topic><topic>Chinese medicine</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Density</topic><topic>Family medical history</topic><topic>Fatty liver</topic><topic>Female</topic><topic>Females</topic><topic>Gastroenterology</topic><topic>Gastrointestinal surgery</topic><topic>Hepatitis</topic><topic>Hepatology</topic><topic>High density lipoprotein</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Identification methods</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Low density lipoprotein</topic><topic>Low density lipoproteins</topic><topic>Male</topic><topic>Males</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Minority &amp; 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Previous studies have shown that some metabolic risk factors are related to nonalcoholic fatty liver disease (NAFLD). This retrospective study was performed to investigate the associations between physical examinations and blood biochemistry parameters and NAFLD status and to identify possible risk factors of NAFLD. Methods. Study participants underwent general physical examinations, blood biochemistry, and abdominal ultrasound evaluations. In addition, data regarding sex, age, ethnicity, medical history, and alcohol consumption of participants were recorded. Among the study participants (N=1994), 57.8% were male, 41.2% over the age of 50, and 52.6% with BMI≥24. 986 patients had NAFLD and 1008 had no NAFLD. We used effect size analysis and logistic regression to determine which physical examinations and blood biochemistry parameters were significant for the association between these parameters and NAFLD status. Results. Both the effect size and logistic regression indicated that BMI, diastolic blood pressure (DBP), triglycerides (TG), and serum uric acid (SUA) show a significant association with NAFLD. Females are overall at a higher risk of NAFLD, but factors such as high BMI, DBP, TG, and SUA increase the associated risk for both sexes. Compared with males, females have a higher risk of NAFLD given that they are over 50, overweight and obese (BMI at or over 24), or have high SUA. In terms of age, people older than 50 with high SUA, and people younger than 50 with high DBP and low-density lipoprotein cholesterol (LDL-C) all increase the risk of NAFLD. For BMI, high DBP and low high-density lipoprotein cholesterol (HDL-C) are risk factors for NAFLD in overweight and obese people (BMI at or over 24), whereas in normal weight and underweight people (BMI under 24), elevated LDL-C increases the risk of NAFLD. Conclusions. Our results revealed sex, age, and BMI modulate the association of physical examinations and blood biochemistry parameters and NAFLD, which may facilitate the development of personalized early warning and prevention strategies of NAFLD for at-risk populations.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31341886</pmid><doi>10.1155/2019/1246518</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6197-8836</orcidid><orcidid>https://orcid.org/0000-0001-9374-2369</orcidid><orcidid>https://orcid.org/0000-0003-3619-8090</orcidid><orcidid>https://orcid.org/0000-0002-0280-7495</orcidid><orcidid>https://orcid.org/0000-0001-7574-9401</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 2314-6133
ispartof BioMed research international, 2019-01, Vol.2019 (2019), p.1-7
issn 2314-6133
2314-6141
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6612989
source MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access
subjects Abdomen
Adult
Age
Alcohol
Alcoholic beverages
Biochemistry
Blood pressure
Body mass
Body Mass Index
Body weight
China
Chinese medicine
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Density
Family medical history
Fatty liver
Female
Females
Gastroenterology
Gastrointestinal surgery
Hepatitis
Hepatology
High density lipoprotein
Hospitals
Humans
Identification methods
Liver
Liver diseases
Low density lipoprotein
Low density lipoproteins
Male
Males
Medical research
Medicine, Experimental
Metabolism
Middle Aged
Minority & ethnic groups
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - diagnostic imaging
Obesity
Obesity - blood
Obesity - diagnostic imaging
Overweight
Parameter identification
Periodic health examinations
Physical diagnosis
Physical examinations
Prospective Studies
Regression analysis
Retrospective Studies
Risk analysis
Risk Factors
Sex
Studies
Systematic review
Triglycerides
Ultrasonic imaging
Ultrasound
Underweight
Uric acid
title Sex, Age, and BMI Modulate the Association of Physical Examinations and Blood Biochemistry Parameters and NAFLD: A Retrospective Study on 1994 Cases Observed at Shuguang Hospital, China
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