Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice

Cav1.2 is the pore‐forming subunit of L‐type voltage‐gated calcium channel (LTCC) that plays an important role in calcium overload and cell death in Alzheimer's disease. LTCC activity can be regulated by estrogen, a sex steroid hormone that is neuroprotective. Here, we investigated the potentia...

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Veröffentlicht in:	Aging cell 2019-08, Vol.18 (4), p.e12961-n/a
Hauptverfasser:	Lai, Yu‐Jie, Zhu, Bing‐Lin, Sun, Fei, Luo, Dong, Ma, Yuan‐Lin, Luo, Bio, Tang, Jing, Xiong, Ming‐Jian, Liu, Lu, Long, Yan, Hu, Xiao‐Tong, He, Ling, Deng, Xiao‐Juan, Zhang, John H., Yang, Jian, Yan, Zhen, Chen, Guo‐Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amino acid sequence Amyloid beta-Protein Precursor - genetics Animals Calcium Calcium channels Calcium channels (voltage-gated) Calcium Channels, L-Type - metabolism Cav1.2 Cell death Cell Line, Tumor Cognitive ability Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism Disease Models, Animal Estradiol Estradiol - pharmacology Estrogen Receptor alpha - agonists Estrogen Receptor alpha - metabolism Estrogen receptor α Female Gene Knockdown Techniques Humans K29 Leupeptins - pharmacology Ligases Lysine Mdm2 MDM2 protein Mice - embryology Mice, Inbred C57BL Mice, Transgenic Neurodegenerative diseases Neurons Neurons - metabolism Neuroprotection Oligopeptides - genetics Original Paper Original Papers Ovariectomy Phenols Phenols - pharmacology Phenols - therapeutic use Presenilin 1 Proteasome Inhibitors - pharmacology Proteasomes Protein binding Proteins Proteolysis - drug effects Proto-Oncogene Proteins c-mdm2 - genetics Pyrazoles - pharmacology Pyrazoles - therapeutic use Transfection Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitination Ubiquitination - drug effects
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