Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults
Here, we investigated the relationship of the age‐associated expansion of IL‐7 receptor alpha low (IL‐7Rαlow) effector memory (EM) CD8+ T cells with the global transcriptomic profile of peripheral blood cells in humans. We found 231 aging signature genes of IL‐7Rαlow EM CD8+ T cells that corresponde...
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| Veröffentlicht in: | Aging cell 2019-08, Vol.18 (4), p.e12960-n/a |
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| creator | Park, Hong‐Jai Shin, Min Sun Kim, Minhyung Bilsborrow, Joshua B. Mohanty, Subhasis Montgomery, Ruth R. Shaw, Albert C. You, Sungyong Kang, Insoo |
| description | Here, we investigated the relationship of the age‐associated expansion of IL‐7 receptor alpha low (IL‐7Rαlow) effector memory (EM) CD8+ T cells with the global transcriptomic profile of peripheral blood cells in humans. We found 231 aging signature genes of IL‐7Rαlow EM CD8+ T cells that corresponded to 15% of the age‐associated genes (231/1,497) reported by a meta‐analysis study on human peripheral whole blood from approximately 15,000 individuals, having high correlation with chronological age. These aging signature genes were the target genes of several transcription factors including MYC, SATB1, and BATF, which also belonged to the 231 genes, supporting the upstream regulatory role of these transcription factors in altering the gene expression profile of peripheral blood cells with aging. We validated the differential expression of these transcription factors between IL‐7Rαlow and high EM CD8+ T cells as well as in peripheral blood mononuclear cells (PBMCs) of young and older adults. Finally, we found a significant association with influenza vaccine responses in older adults, suggesting the possible biological significance of the aging signature genes of IL‐7Rαlow EM CD8+ T cells. The results of our study support the relationship of the expansion of IL‐7Rαlow EM CD8+ T cells with the age‐associated changes in the gene expression profile of peripheral blood cells and its possible biological implications.
Human effector memory (EM) CD8+ T cells expressing low levels of IL‐7 receptor alpha chain (IL‐7Rα), which expand with aging, have a unique set of genes (e.g. GZMH, FGFBP2, CX3CR1) that correlate with chronological age. These genes referred to as the aging signature genes of IL‐7Rα EM CD8+ T cells are targeted largely by the transcription factors MYC, SATB1 and BATF, and associated with influenza vaccine responses in older adults. |
| doi_str_mv | 10.1111/acel.12960 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6612637</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A707859793</galeid><sourcerecordid>A707859793</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3600-1c3519e49fd4c9a6b46c7ab3d9b0f405924a56dad75bc03295241cada93bec613</originalsourceid><addsrcrecordid>eNp9ks2O0zAQgCMEYpeFCw-ALHFBoBY7_74gVWWBlSpxWc7WxJ60XhK72ElX5cQj8D68DU_ChC6FRQjn4MjzzWd7PEnyWPC5oPESNHZzkcqS30lORV7lM1ml5d3jv6hPkgcxXnEuKsmz-8lJJnieFyI9Tb5dBnBRB7sdfG81AwfdPtrIfMs2Yw-OXay-f_lasYAaiQkMuu0GWOeviTVsY9cbhm2Leor12PuwZ8vX9Qt2yehYXaTEHQLNpII1kgti9NrCgIZFu3YwjAFZZ91HWhg8s67tRnSfge1Aa-uQDHHrXUQKMd8ZpDOYsRviw-ReS2Z8dDOfJR_enF8u381W799eLBermc5KzmdCZ4WQmMvW5FpC2eSlrqDJjGx4m_NCpjkUpQFTFY3mWSqLNBcaDMisQV2K7Cx5dfBux6ZHo9ENATq1DbaHsFcerLodcXaj1n6nylKkZVaR4NmNIPhPI8ZB9TZO1QGHfowqTUUtZV2IktCnf6FXfgz0KBNVpLKWVZH_ptbQoaKKedpXT1K1qHhVF7KSGVHzf1D0GaSn9g5bS-u3Ep4fEnTwMQZsj3cUXE2tpqZWUz9bjeAnf1bliP7qLQLEAbimbfb_UanF8nx1kP4AGQHi3A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2252989754</pqid></control><display><type>article</type><title>Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Park, Hong‐Jai ; Shin, Min Sun ; Kim, Minhyung ; Bilsborrow, Joshua B. ; Mohanty, Subhasis ; Montgomery, Ruth R. ; Shaw, Albert C. ; You, Sungyong ; Kang, Insoo</creator><creatorcontrib>Park, Hong‐Jai ; Shin, Min Sun ; Kim, Minhyung ; Bilsborrow, Joshua B. ; Mohanty, Subhasis ; Montgomery, Ruth R. ; Shaw, Albert C. ; You, Sungyong ; Kang, Insoo</creatorcontrib><description>Here, we investigated the relationship of the age‐associated expansion of IL‐7 receptor alpha low (IL‐7Rαlow) effector memory (EM) CD8+ T cells with the global transcriptomic profile of peripheral blood cells in humans. We found 231 aging signature genes of IL‐7Rαlow EM CD8+ T cells that corresponded to 15% of the age‐associated genes (231/1,497) reported by a meta‐analysis study on human peripheral whole blood from approximately 15,000 individuals, having high correlation with chronological age. These aging signature genes were the target genes of several transcription factors including MYC, SATB1, and BATF, which also belonged to the 231 genes, supporting the upstream regulatory role of these transcription factors in altering the gene expression profile of peripheral blood cells with aging. We validated the differential expression of these transcription factors between IL‐7Rαlow and high EM CD8+ T cells as well as in peripheral blood mononuclear cells (PBMCs) of young and older adults. Finally, we found a significant association with influenza vaccine responses in older adults, suggesting the possible biological significance of the aging signature genes of IL‐7Rαlow EM CD8+ T cells. The results of our study support the relationship of the expansion of IL‐7Rαlow EM CD8+ T cells with the age‐associated changes in the gene expression profile of peripheral blood cells and its possible biological implications.
Human effector memory (EM) CD8+ T cells expressing low levels of IL‐7 receptor alpha chain (IL‐7Rα), which expand with aging, have a unique set of genes (e.g. GZMH, FGFBP2, CX3CR1) that correlate with chronological age. These genes referred to as the aging signature genes of IL‐7Rα EM CD8+ T cells are targeted largely by the transcription factors MYC, SATB1 and BATF, and associated with influenza vaccine responses in older adults.</description><identifier>ISSN: 1474-9718</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/acel.12960</identifier><identifier>PMID: 31044512</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adult ; Age ; Aged ; Aging ; Aging - immunology ; Analysis ; Blood ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Cohort Studies ; Effector cells ; Female ; Gene expression ; Gene Expression Profiling - methods ; Gene Regulatory Networks - genetics ; Genes ; Healthy Volunteers ; human ; Humans ; IL‐7 receptor alpha ; Immunologic Memory - immunology ; Immunological memory ; Influenza ; Influenza vaccines ; Influenza Vaccines - immunology ; Leukocytes (mononuclear) ; Lymphocytes ; Lymphocytes T ; Male ; Memory (Computers) ; memory CD8+ T cells ; Memory cells ; Middle Aged ; Myc protein ; Older people ; Original ; Peripheral blood mononuclear cells ; Receptors, Interleukin-7 - genetics ; T cells ; Transcription factors ; Transcription Factors - genetics ; Transcriptome ; vaccine response ; Vaccines ; Young Adult</subject><ispartof>Aging cell, 2019-08, Vol.18 (4), p.e12960-n/a</ispartof><rights>2019 The Authors. published by the Anatomical Society and John Wiley & Sons Ltd.</rights><rights>2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3600-1c3519e49fd4c9a6b46c7ab3d9b0f405924a56dad75bc03295241cada93bec613</citedby><cites>FETCH-LOGICAL-c3600-1c3519e49fd4c9a6b46c7ab3d9b0f405924a56dad75bc03295241cada93bec613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612637/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612637/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31044512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Hong‐Jai</creatorcontrib><creatorcontrib>Shin, Min Sun</creatorcontrib><creatorcontrib>Kim, Minhyung</creatorcontrib><creatorcontrib>Bilsborrow, Joshua B.</creatorcontrib><creatorcontrib>Mohanty, Subhasis</creatorcontrib><creatorcontrib>Montgomery, Ruth R.</creatorcontrib><creatorcontrib>Shaw, Albert C.</creatorcontrib><creatorcontrib>You, Sungyong</creatorcontrib><creatorcontrib>Kang, Insoo</creatorcontrib><title>Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults</title><title>Aging cell</title><addtitle>Aging Cell</addtitle><description>Here, we investigated the relationship of the age‐associated expansion of IL‐7 receptor alpha low (IL‐7Rαlow) effector memory (EM) CD8+ T cells with the global transcriptomic profile of peripheral blood cells in humans. We found 231 aging signature genes of IL‐7Rαlow EM CD8+ T cells that corresponded to 15% of the age‐associated genes (231/1,497) reported by a meta‐analysis study on human peripheral whole blood from approximately 15,000 individuals, having high correlation with chronological age. These aging signature genes were the target genes of several transcription factors including MYC, SATB1, and BATF, which also belonged to the 231 genes, supporting the upstream regulatory role of these transcription factors in altering the gene expression profile of peripheral blood cells with aging. We validated the differential expression of these transcription factors between IL‐7Rαlow and high EM CD8+ T cells as well as in peripheral blood mononuclear cells (PBMCs) of young and older adults. Finally, we found a significant association with influenza vaccine responses in older adults, suggesting the possible biological significance of the aging signature genes of IL‐7Rαlow EM CD8+ T cells. The results of our study support the relationship of the expansion of IL‐7Rαlow EM CD8+ T cells with the age‐associated changes in the gene expression profile of peripheral blood cells and its possible biological implications.
Human effector memory (EM) CD8+ T cells expressing low levels of IL‐7 receptor alpha chain (IL‐7Rα), which expand with aging, have a unique set of genes (e.g. GZMH, FGFBP2, CX3CR1) that correlate with chronological age. These genes referred to as the aging signature genes of IL‐7Rα EM CD8+ T cells are targeted largely by the transcription factors MYC, SATB1 and BATF, and associated with influenza vaccine responses in older adults.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - immunology</subject><subject>Analysis</subject><subject>Blood</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cohort Studies</subject><subject>Effector cells</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Regulatory Networks - genetics</subject><subject>Genes</subject><subject>Healthy Volunteers</subject><subject>human</subject><subject>Humans</subject><subject>IL‐7 receptor alpha</subject><subject>Immunologic Memory - immunology</subject><subject>Immunological memory</subject><subject>Influenza</subject><subject>Influenza vaccines</subject><subject>Influenza Vaccines - immunology</subject><subject>Leukocytes (mononuclear)</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Memory (Computers)</subject><subject>memory CD8+ T cells</subject><subject>Memory cells</subject><subject>Middle Aged</subject><subject>Myc protein</subject><subject>Older people</subject><subject>Original</subject><subject>Peripheral blood mononuclear cells</subject><subject>Receptors, Interleukin-7 - genetics</subject><subject>T cells</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcriptome</subject><subject>vaccine response</subject><subject>Vaccines</subject><subject>Young Adult</subject><issn>1474-9718</issn><issn>1474-9726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks2O0zAQgCMEYpeFCw-ALHFBoBY7_74gVWWBlSpxWc7WxJ60XhK72ElX5cQj8D68DU_ChC6FRQjn4MjzzWd7PEnyWPC5oPESNHZzkcqS30lORV7lM1ml5d3jv6hPkgcxXnEuKsmz-8lJJnieFyI9Tb5dBnBRB7sdfG81AwfdPtrIfMs2Yw-OXay-f_lasYAaiQkMuu0GWOeviTVsY9cbhm2Leor12PuwZ8vX9Qt2yehYXaTEHQLNpII1kgti9NrCgIZFu3YwjAFZZ91HWhg8s67tRnSfge1Aa-uQDHHrXUQKMd8ZpDOYsRviw-ReS2Z8dDOfJR_enF8u381W799eLBermc5KzmdCZ4WQmMvW5FpC2eSlrqDJjGx4m_NCpjkUpQFTFY3mWSqLNBcaDMisQV2K7Cx5dfBux6ZHo9ENATq1DbaHsFcerLodcXaj1n6nylKkZVaR4NmNIPhPI8ZB9TZO1QGHfowqTUUtZV2IktCnf6FXfgz0KBNVpLKWVZH_ptbQoaKKedpXT1K1qHhVF7KSGVHzf1D0GaSn9g5bS-u3Ep4fEnTwMQZsj3cUXE2tpqZWUz9bjeAnf1bliP7qLQLEAbimbfb_UanF8nx1kP4AGQHi3A</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Park, Hong‐Jai</creator><creator>Shin, Min Sun</creator><creator>Kim, Minhyung</creator><creator>Bilsborrow, Joshua B.</creator><creator>Mohanty, Subhasis</creator><creator>Montgomery, Ruth R.</creator><creator>Shaw, Albert C.</creator><creator>You, Sungyong</creator><creator>Kang, Insoo</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201908</creationdate><title>Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults</title><author>Park, Hong‐Jai ; Shin, Min Sun ; Kim, Minhyung ; Bilsborrow, Joshua B. ; Mohanty, Subhasis ; Montgomery, Ruth R. ; Shaw, Albert C. ; You, Sungyong ; Kang, Insoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3600-1c3519e49fd4c9a6b46c7ab3d9b0f405924a56dad75bc03295241cada93bec613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - immunology</topic><topic>Analysis</topic><topic>Blood</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cohort Studies</topic><topic>Effector cells</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Regulatory Networks - genetics</topic><topic>Genes</topic><topic>Healthy Volunteers</topic><topic>human</topic><topic>Humans</topic><topic>IL‐7 receptor alpha</topic><topic>Immunologic Memory - immunology</topic><topic>Immunological memory</topic><topic>Influenza</topic><topic>Influenza vaccines</topic><topic>Influenza Vaccines - immunology</topic><topic>Leukocytes (mononuclear)</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Memory (Computers)</topic><topic>memory CD8+ T cells</topic><topic>Memory cells</topic><topic>Middle Aged</topic><topic>Myc protein</topic><topic>Older people</topic><topic>Original</topic><topic>Peripheral blood mononuclear cells</topic><topic>Receptors, Interleukin-7 - genetics</topic><topic>T cells</topic><topic>Transcription factors</topic><topic>Transcription Factors - genetics</topic><topic>Transcriptome</topic><topic>vaccine response</topic><topic>Vaccines</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Hong‐Jai</creatorcontrib><creatorcontrib>Shin, Min Sun</creatorcontrib><creatorcontrib>Kim, Minhyung</creatorcontrib><creatorcontrib>Bilsborrow, Joshua B.</creatorcontrib><creatorcontrib>Mohanty, Subhasis</creatorcontrib><creatorcontrib>Montgomery, Ruth R.</creatorcontrib><creatorcontrib>Shaw, Albert C.</creatorcontrib><creatorcontrib>You, Sungyong</creatorcontrib><creatorcontrib>Kang, Insoo</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Hong‐Jai</au><au>Shin, Min Sun</au><au>Kim, Minhyung</au><au>Bilsborrow, Joshua B.</au><au>Mohanty, Subhasis</au><au>Montgomery, Ruth R.</au><au>Shaw, Albert C.</au><au>You, Sungyong</au><au>Kang, Insoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults</atitle><jtitle>Aging cell</jtitle><addtitle>Aging Cell</addtitle><date>2019-08</date><risdate>2019</risdate><volume>18</volume><issue>4</issue><spage>e12960</spage><epage>n/a</epage><pages>e12960-n/a</pages><issn>1474-9718</issn><eissn>1474-9726</eissn><abstract>Here, we investigated the relationship of the age‐associated expansion of IL‐7 receptor alpha low (IL‐7Rαlow) effector memory (EM) CD8+ T cells with the global transcriptomic profile of peripheral blood cells in humans. We found 231 aging signature genes of IL‐7Rαlow EM CD8+ T cells that corresponded to 15% of the age‐associated genes (231/1,497) reported by a meta‐analysis study on human peripheral whole blood from approximately 15,000 individuals, having high correlation with chronological age. These aging signature genes were the target genes of several transcription factors including MYC, SATB1, and BATF, which also belonged to the 231 genes, supporting the upstream regulatory role of these transcription factors in altering the gene expression profile of peripheral blood cells with aging. We validated the differential expression of these transcription factors between IL‐7Rαlow and high EM CD8+ T cells as well as in peripheral blood mononuclear cells (PBMCs) of young and older adults. Finally, we found a significant association with influenza vaccine responses in older adults, suggesting the possible biological significance of the aging signature genes of IL‐7Rαlow EM CD8+ T cells. The results of our study support the relationship of the expansion of IL‐7Rαlow EM CD8+ T cells with the age‐associated changes in the gene expression profile of peripheral blood cells and its possible biological implications.
Human effector memory (EM) CD8+ T cells expressing low levels of IL‐7 receptor alpha chain (IL‐7Rα), which expand with aging, have a unique set of genes (e.g. GZMH, FGFBP2, CX3CR1) that correlate with chronological age. These genes referred to as the aging signature genes of IL‐7Rα EM CD8+ T cells are targeted largely by the transcription factors MYC, SATB1 and BATF, and associated with influenza vaccine responses in older adults.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>31044512</pmid><doi>10.1111/acel.12960</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Aging Aging - immunology Analysis Blood CD8 antigen CD8-Positive T-Lymphocytes - immunology Cohort Studies Effector cells Female Gene expression Gene Expression Profiling - methods Gene Regulatory Networks - genetics Genes Healthy Volunteers human Humans IL‐7 receptor alpha Immunologic Memory - immunology Immunological memory Influenza Influenza vaccines Influenza Vaccines - immunology Leukocytes (mononuclear) Lymphocytes Lymphocytes T Male Memory (Computers) memory CD8+ T cells Memory cells Middle Aged Myc protein Older people Original Peripheral blood mononuclear cells Receptors, Interleukin-7 - genetics T cells Transcription factors Transcription Factors - genetics Transcriptome vaccine response Vaccines Young Adult |
| title | Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults |
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