T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients

To the Editor: Dedicator of cytokinesis 2 (DOCK2) is a guanine nucleotide exchange factor expressed predominantly in hematopoietic cells that activates the Rac GTPases.1,2 Biallelic mutations in DOCK2 cause a combined immunodeficiency with T-cell lymphopenia and impaired T-cell activation.1,3 The me...

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