HLA-A32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS), which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy, affecting future treatment choices. Variatio...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2019-07, Vol.144 (1), p.183-192
Hauptverfasser:	Konvinse, Katherine C., Trubiano, Jason A., Pavlos, Rebecca, James, Ian, Shaffer, Christian M., Bejan, Cosmin A., Schutte, Ryan J., Ostrov, David A., Pilkinton, Mark A., Rosenbach, Misha, Zwerner, Jeffrey P., Williams, Kristina B., Bourke, Jack, Martinez, Patricia, Rwandamuriye, Francois, Chopra, Abha, Watson, Mark, Redwood, Alec J., White, Katie D., Mallal, Simon A., Phillips, Elizabeth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alleles Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - chemistry antibiotic allergy Antibiotics Blood diseases delayed hypersensitivity Deoxyribonucleic acid DNA Drug Hypersensitivity Syndrome - etiology Drug Hypersensitivity Syndrome - immunology drug reaction with eosinophilia and systemic symptoms Drug screening E coli Electronic medical records Eosinophilia Female Gastrointestinal surgery Histocompatibility antigen HLA HLA-A Antigens - chemistry HLA-A Antigens - immunology human leukocyte antigen Humans Hypersensitivity Lymphocytes Lymphocytes T Male Middle Aged Molecular Docking Simulation Morbidity Mortality Patients Side effects Software Staphylococcus infections T-cell hypersensitivity Vancomycin Vancomycin - adverse effects Vancomycin - chemistry Young Adult
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