Group A Streptococcus Adsorbed Vaccine: Repeated Intramuscular Dose Toxicity Test in Minipigs

Streptococcus pyogenes infection continues to be a worldwide public health problem causing various diseases in humans and plays an important role in the pathogenesis of rheumatic fever and rheumatic heart disease. We developed a vaccine candidate to prevent S. pyogenes infections, identified as Stre...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.9733-12, Article 9733
Hauptverfasser:	Postol, Edilberto, Sá-Rocha, Luiz C., Sampaio, Roney O., Demarchi, Lea M. M. F., Alencar, Raquel E., Abduch, Maria C. D., Kalil, Jorge, Guilherme, Luiza
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/51 59 631/250 64 692/4019/2773 Adsorption Animal models Animals Cardiac function Cardiovascular diseases Coronary artery disease Echocardiography Female Heart diseases Humanities and Social Sciences Injections, Intramuscular Male Models, Animal multidisciplinary Public health Rheumatic fever Rheumatic heart disease Science Science (multidisciplinary) Streptococcal Infections - prevention & control Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - adverse effects Streptococcus Streptococcus infections Streptococcus pyogenes - immunology Swine Swine, Miniature Toxicity Toxicity Tests Vaccines Valves
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