Bile cell‑free DNA as a novel and powerful liquid biopsy for detecting somatic variants in biliary tract cancer

Tissue sampling of biliary tract carcinomas (BTCs) for molecular characterization is challenging. The aim of this study was to investigate the possibility of identifying individual actionable mutations derived from bile cell‑free DNA (cfDNA) using targeted deep sequencing. Ten BTC patients, four wit...

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Veröffentlicht in:	Oncology reports 2019-08, Vol.42 (2), p.549-560
Hauptverfasser:	Shen, Ningjia, Zhang, Dadong, Yin, Lei, Qiu, Yinghe, Liu, Jian, Yu, Wenlong, Fu, Xiaohui, Zhu, Bin, Xu, Xiaoya, Duan, Anqi, Chen, Zishuo, Wang, Xiang, Cao, Xinkai, Zhao, Teng, Zhou, Zisong, Yu, Lianghe, Qin, Hao, Fang, Zheng, Li, Jing-Yu, Liu, Yuanjin, Xiong, Lei, Yuan, Bo, Li, Fugen, Zhang, Yongjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Antigens Bile Biliary tract cancer Biliary Tract Neoplasms - classification Biliary Tract Neoplasms - diagnosis Biliary Tract Neoplasms - genetics Biomarkers, Tumor - genetics Cancer Cancer genetics Cell-Free Nucleic Acids - analysis Cell-Free Nucleic Acids - genetics Cholangiocarcinoma Deoxyribonucleic acid DNA DNA Copy Number Variations DNA, Neoplasm - analysis DNA, Neoplasm - genetics Female Follow-Up Studies Gallbladder Gallbladder cancer Genes Genetic research High-Throughput Nucleotide Sequencing Humans Liquid Biopsy - methods Male Middle Aged Mutation Patients Prognosis Tumors
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