Initial clinical outcomes and prognostic variables in the implementation of a Code Sepsis in a high complexity University Hospital
To assess the impact of the first months of application of a Code Sepsis in a high complexity hospital, analyzing patient´s epidemiological and clinical characteristics and prognostic factors. A long-term observational study was carried out throughout a consecutive period of seven months (February 2...
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| Veröffentlicht in: | Revista española de quimioterapia 2019-06, Vol.32 (3), p.238-245 |
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| creator | Ramasco, F Figuerola, A Mendez, R Rodríguez Serrano, D von Wernitz, A Hernández-Aceituno, A Sáez, C Cardeñoso, L Martin, E García-Vázquez, N de Las Cuevas, C Pascual, N Bautista, A Jiménez, D Fernández, G Leal, A Vinuesa, M Pizarro, A di Martino, M Del Campo, L García Sanz, I Chicot, M Barrios, A Rubio, M J |
| description | To assess the impact of the first months of application of a Code Sepsis in a high complexity hospital, analyzing patient´s epidemiological and clinical characteristics and prognostic factors.
A long-term observational study was carried out throughout a consecutive period of seven months (February 2015 - September 2015). The relationship with mortality of risk factors, and analytic values was analyzed using uni- and multivariate analyses.
A total of 237 patients were included. The in-hospital mortality was 24% at 30 days and 27% at 60 days. The mortality of patients admitted to Critical Care Units was 30%. Significant differences were found between the patients who died and those who survived in mean levels of creatinine (2.30 vs 1.46 mg/dL, p |
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A long-term observational study was carried out throughout a consecutive period of seven months (February 2015 - September 2015). The relationship with mortality of risk factors, and analytic values was analyzed using uni- and multivariate analyses.
A total of 237 patients were included. The in-hospital mortality was 24% at 30 days and 27% at 60 days. The mortality of patients admitted to Critical Care Units was 30%. Significant differences were found between the patients who died and those who survived in mean levels of creatinine (2.30 vs 1.46 mg/dL, p <0.05), lactic acid (6.10 vs 2.62 mmol/L, p <0.05) and procalcitonin (23.27 vs 12.73 mg/dL, p<0.05). A statistically significant linear trend was found between SOFA scale rating and mortality (p<0.05). In the multivariate analysis additional independent risk factors associated with death were identified: age > 65 years (OR 5.33, p <0.05), lactic acid > 3 mmol/L (OR 5,85, p <0,05), creatinine > 1,2 mgr /dL (OR 4,54, p <0,05) and shock (OR 6,57, P <0,05).
The epidemiological, clinical and mortality characteristics of the patients in our series are similar to the best published in the literature. The study has identified several markers that could be useful at a local level to estimate risk of death in septic patients. Studies like this one are necessary to make improvements in the Code Sepsis programs.]]></description><identifier>ISSN: 0214-3429</identifier><identifier>EISSN: 1988-9518</identifier><identifier>PMID: 30968675</identifier><language>eng</language><publisher>Spain: Sociedad Española de Quimioterapia</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; APACHE ; Biomarkers ; Clinical Protocols ; Creatinine - blood ; Female ; Hospital Mortality - trends ; Hospitals, University ; Humans ; Lactic Acid - blood ; Male ; Middle Aged ; Original ; Procalcitonin - blood ; Prognosis ; Risk Factors ; Sepsis - mortality ; Sepsis - therapy ; Treatment Outcome</subject><ispartof>Revista española de quimioterapia, 2019-06, Vol.32 (3), p.238-245</ispartof><rights>The Author 2019. Published by Sociedad Española de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).</rights><rights>The Author 2019 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609936/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609936/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30968675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramasco, F</creatorcontrib><creatorcontrib>Figuerola, A</creatorcontrib><creatorcontrib>Mendez, R</creatorcontrib><creatorcontrib>Rodríguez Serrano, D</creatorcontrib><creatorcontrib>von Wernitz, A</creatorcontrib><creatorcontrib>Hernández-Aceituno, A</creatorcontrib><creatorcontrib>Sáez, C</creatorcontrib><creatorcontrib>Cardeñoso, L</creatorcontrib><creatorcontrib>Martin, E</creatorcontrib><creatorcontrib>García-Vázquez, N</creatorcontrib><creatorcontrib>de Las Cuevas, C</creatorcontrib><creatorcontrib>Pascual, N</creatorcontrib><creatorcontrib>Bautista, A</creatorcontrib><creatorcontrib>Jiménez, D</creatorcontrib><creatorcontrib>Fernández, G</creatorcontrib><creatorcontrib>Leal, A</creatorcontrib><creatorcontrib>Vinuesa, M</creatorcontrib><creatorcontrib>Pizarro, A</creatorcontrib><creatorcontrib>di Martino, M</creatorcontrib><creatorcontrib>Del Campo, L</creatorcontrib><creatorcontrib>García Sanz, I</creatorcontrib><creatorcontrib>Chicot, M</creatorcontrib><creatorcontrib>Barrios, A</creatorcontrib><creatorcontrib>Rubio, M J</creatorcontrib><creatorcontrib>And the members of de Code Sepsis H.U de La Princesa</creatorcontrib><title>Initial clinical outcomes and prognostic variables in the implementation of a Code Sepsis in a high complexity University Hospital</title><title>Revista española de quimioterapia</title><addtitle>Rev Esp Quimioter</addtitle><description><![CDATA[To assess the impact of the first months of application of a Code Sepsis in a high complexity hospital, analyzing patient´s epidemiological and clinical characteristics and prognostic factors.
A long-term observational study was carried out throughout a consecutive period of seven months (February 2015 - September 2015). The relationship with mortality of risk factors, and analytic values was analyzed using uni- and multivariate analyses.
A total of 237 patients were included. The in-hospital mortality was 24% at 30 days and 27% at 60 days. The mortality of patients admitted to Critical Care Units was 30%. Significant differences were found between the patients who died and those who survived in mean levels of creatinine (2.30 vs 1.46 mg/dL, p <0.05), lactic acid (6.10 vs 2.62 mmol/L, p <0.05) and procalcitonin (23.27 vs 12.73 mg/dL, p<0.05). A statistically significant linear trend was found between SOFA scale rating and mortality (p<0.05). In the multivariate analysis additional independent risk factors associated with death were identified: age > 65 years (OR 5.33, p <0.05), lactic acid > 3 mmol/L (OR 5,85, p <0,05), creatinine > 1,2 mgr /dL (OR 4,54, p <0,05) and shock (OR 6,57, P <0,05).
The epidemiological, clinical and mortality characteristics of the patients in our series are similar to the best published in the literature. The study has identified several markers that could be useful at a local level to estimate risk of death in septic patients. Studies like this one are necessary to make improvements in the Code Sepsis programs.]]></description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>APACHE</subject><subject>Biomarkers</subject><subject>Clinical Protocols</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Hospital Mortality - trends</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Lactic Acid - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Procalcitonin - blood</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Sepsis - mortality</subject><subject>Sepsis - therapy</subject><subject>Treatment Outcome</subject><issn>0214-3429</issn><issn>1988-9518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE9Lw0AUxIMotla_guzRS2Czm2ySiyBFrVDwoD2Hl_3TPtnsxuy22Kuf3KhV9PQGZvjNY46SaVZXVVoXWXWcTCnL8pTnrJ4kZyG8UJrzvM5OkwmntahEWUyT9weHEcESadGhHIXfRuk7HQg4RfrBr50PESXZwYDQ2tFAR-JGE-x6qzvtIkT0jnhDgMy90uRJ9wG_YkA2uN6QkTdG3zDuycrhTg_hUy586DGCPU9ODNigLw53lqzubp_ni3T5eP8wv1mmPRMipipjwFrNK0FNrfOcmzYDIQtTFqYyVFLFmFFlCaVSnJrcqFxzkKKUZTZaBZ8l19_cftt2Wsnx8wFs0w_YwbBvPGDz33G4adZ-1whB65qLEXB1AAz-datDbDoMUlsLTvttaBijZVZUjFdj9PJv12_Jz_D8A783hO4</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Ramasco, F</creator><creator>Figuerola, A</creator><creator>Mendez, R</creator><creator>Rodríguez Serrano, D</creator><creator>von Wernitz, A</creator><creator>Hernández-Aceituno, A</creator><creator>Sáez, C</creator><creator>Cardeñoso, L</creator><creator>Martin, E</creator><creator>García-Vázquez, N</creator><creator>de Las Cuevas, C</creator><creator>Pascual, N</creator><creator>Bautista, A</creator><creator>Jiménez, D</creator><creator>Fernández, G</creator><creator>Leal, A</creator><creator>Vinuesa, M</creator><creator>Pizarro, A</creator><creator>di Martino, M</creator><creator>Del Campo, L</creator><creator>García Sanz, I</creator><creator>Chicot, M</creator><creator>Barrios, A</creator><creator>Rubio, M J</creator><general>Sociedad Española de Quimioterapia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190601</creationdate><title>Initial clinical outcomes and prognostic variables in the implementation of a Code Sepsis in a high complexity University Hospital</title><author>Ramasco, F ; 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A long-term observational study was carried out throughout a consecutive period of seven months (February 2015 - September 2015). The relationship with mortality of risk factors, and analytic values was analyzed using uni- and multivariate analyses.
A total of 237 patients were included. The in-hospital mortality was 24% at 30 days and 27% at 60 days. The mortality of patients admitted to Critical Care Units was 30%. Significant differences were found between the patients who died and those who survived in mean levels of creatinine (2.30 vs 1.46 mg/dL, p <0.05), lactic acid (6.10 vs 2.62 mmol/L, p <0.05) and procalcitonin (23.27 vs 12.73 mg/dL, p<0.05). A statistically significant linear trend was found between SOFA scale rating and mortality (p<0.05). In the multivariate analysis additional independent risk factors associated with death were identified: age > 65 years (OR 5.33, p <0.05), lactic acid > 3 mmol/L (OR 5,85, p <0,05), creatinine > 1,2 mgr /dL (OR 4,54, p <0,05) and shock (OR 6,57, P <0,05).
The epidemiological, clinical and mortality characteristics of the patients in our series are similar to the best published in the literature. The study has identified several markers that could be useful at a local level to estimate risk of death in septic patients. Studies like this one are necessary to make improvements in the Code Sepsis programs.]]></abstract><cop>Spain</cop><pub>Sociedad Española de Quimioterapia</pub><pmid>30968675</pmid><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Revista española de quimioterapia, 2019-06, Vol.32 (3), p.238-245 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Age Factors Aged Aged, 80 and over APACHE Biomarkers Clinical Protocols Creatinine - blood Female Hospital Mortality - trends Hospitals, University Humans Lactic Acid - blood Male Middle Aged Original Procalcitonin - blood Prognosis Risk Factors Sepsis - mortality Sepsis - therapy Treatment Outcome |
| title | Initial clinical outcomes and prognostic variables in the implementation of a Code Sepsis in a high complexity University Hospital |
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