BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors

Cancer cell stemness is essential for enabling malignant progression and clonal evolution. Cancer cell fate is likely determined by complex mechanisms involving both cell-intrinsic pathways and stress signals from tumor microenvironment. In this study, we examined the role of the tumor suppressor BR...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.9702-11, Article 9702
Hauptverfasser:	Kim, Hoon, Lin, Qun, Yun, Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/106 13/109 13/31 13/89 38 38/77 631/67/1347 631/67/327 631/67/71 BRCA1 protein BRCA1 Protein - genetics BRCA1 Protein - metabolism Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell fate Clinical trials DNA repair Drug Resistance, Neoplasm Epigenesis, Genetic Female Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Humanities and Social Sciences Humans Hypoxia Hypoxia - physiopathology Inhibitors multidisciplinary Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Science Science (multidisciplinary) Stem cells Tumor cell lines Tumor cells Tumor Cells, Cultured Tumor suppressor genes Tumors
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