Rapid MALDI mass spectrometry imaging for surgical pathology
Matrix assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) is an emerging analytical technique, which generates spatially resolved proteomic and metabolomic images from tissue specimens. Conventional MALDI MSI processing and data acquisition can take over 30 min, limiting its...
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| Veröffentlicht in: | NPJ precision oncology 2019-07, Vol.3 (1), p.17-17, Article 17 |
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| creator | Basu, Sankha S. Regan, Michael S. Randall, Elizabeth C. Abdelmoula, Walid M. Clark, Amanda R. Gimenez-Cassina Lopez, Begoña Cornett, Dale S. Haase, Andreas Santagata, Sandro Agar, Nathalie Y. R. |
| description | Matrix assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) is an emerging analytical technique, which generates spatially resolved proteomic and metabolomic images from tissue specimens. Conventional MALDI MSI processing and data acquisition can take over 30 min, limiting its clinical utility for intraoperative diagnostics. We present a rapid MALDI MSI method, completed under 5 min, including sample preparation and analysis, providing a workflow compatible with the clinical frozen section procedure. |
| doi_str_mv | 10.1038/s41698-019-0089-y |
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| subjects | 631/1647/245/2160 631/1647/320 631/61/320 692/4017 692/4028/546 Brief Communication Cancer Research Gene Therapy Human Genetics Internal Medicine Ions Mass spectrometry Medicine Medicine & Public Health Oncology Precision medicine Scientific imaging Targeted cancer therapy |
| title | Rapid MALDI mass spectrometry imaging for surgical pathology |
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