Presynaptic calcium channel inhibition underlies CB₁ cannabinoid receptor-mediated suppression of GABA release

CB1 cannabinoid receptors (CB1) are located at axon terminals and effectively control synaptic communication and thereby circuit operation widespread in the CNS. Although it is partially uncovered how CB1 activation leads to the reduction of synaptic excitation, the mechanisms of the decrease of GAB...

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Veröffentlicht in:	The Journal of neuroscience 2014-06, Vol.34 (23), p.7958-7963
Hauptverfasser:	Szabó, Gergely G, Lenkey, Nora, Holderith, Noemi, Andrási, Tibor, Nusser, Zoltan, Hájos, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Brief Communications Calcium - metabolism Calcium Channel Blockers - pharmacology Cholecystokinin - genetics Cholecystokinin - pharmacology Female gamma-Aminobutyric Acid - metabolism Hippocampus - cytology In Vitro Techniques Inhibitory Postsynaptic Potentials - drug effects Inhibitory Postsynaptic Potentials - physiology Interneurons - drug effects Interneurons - physiology Luminescent Proteins - genetics Male Mice Mice, Transgenic omega-Conotoxin GVIA - pharmacology Piperidines - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - metabolism Synapses - drug effects Synapses - physiology
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