Myd88 is required for disease development in a primary Sjögren’s syndrome mouse model

Murine model of primary Sjögren’s syndrome establishes Myd88 as a crucial mediator of local and systemic disease manifestations. Sjögren’s syndrome (SS) is an autoimmune disease that often results in diminished exocrine gland function. SS patients also experience systemic disease manifestations, inc...

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Veröffentlicht in:	Journal of leukocyte biology 2017-12, Vol.102 (6), p.1411-1420
Hauptverfasser:	Kiripolsky, Jeremy, McCabe, Liam G., Gaile, Daniel P., Kramer, Jill M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies, Antinuclear - immunology Autoantibodies Autoantibodies - immunology autoantibody Autoimmune diseases B-Lymphocytes - drug effects B-Lymphocytes - immunology Cross-Linking Reagents - metabolism Disease Models, Animal Disease Progression extraglandular disease Hypergammaglobulinemia Immune system Immunoglobulin G Immunoglobulin M Inflammation - pathology Inflammation, Extracellular Mediators, & Effector Molecules Interleukin 1 Interleukin 1 receptors Interleukin 6 Kidney - drug effects Kidney - pathology Kidneys Lacrimal Apparatus - drug effects Lacrimal Apparatus - pathology Lipopolysaccharides - pharmacology Lung - drug effects Lung - pathology Mice Mice, Inbred NOD MyD88 protein Myeloid Differentiation Factor 88 - metabolism NOD.B10 Receptors, Antigen, B-Cell - metabolism Rodents saliva Salivary Glands - drug effects Salivary Glands - pathology Salivary Glands - physiopathology Salivation - drug effects Signaling Sjogren's syndrome Sjogren's Syndrome - immunology Sjogren's Syndrome - metabolism Sjogren's Syndrome - pathology Sjogren's Syndrome - physiopathology Splenocytes Systemic diseases T-Lymphocytes - drug effects T-Lymphocytes - immunology
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