Neuroglobin Expression Models as a Tool to Study Its Function

Neuroglobin (Ngb) is an evolutionary conserved member of the globin family with a primary expression in neurons of which the exact functions remain elusive. A plethora of in vivo and in vitro model systems has been generated to this day to determine the functional biological roles of Ngb. Here, we p...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2019, Vol.2019 (2019), p.1-17
Hauptverfasser: Dewilde, Sylvia, Ponsaerts, Peter, Van Acker, Zoë P., Luyckx, Evi
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container_end_page 17
container_issue 2019
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container_title Oxidative medicine and cellular longevity
container_volume 2019
creator Dewilde, Sylvia
Ponsaerts, Peter
Van Acker, Zoë P.
Luyckx, Evi
description Neuroglobin (Ngb) is an evolutionary conserved member of the globin family with a primary expression in neurons of which the exact functions remain elusive. A plethora of in vivo and in vitro model systems has been generated to this day to determine the functional biological roles of Ngb. Here, we provide a comprehensive overview and discussion of the different Ngb models, covering animal and cellular models of both overexpression and knockout strategies. Intriguingly, an in-depth literature search of available Ngb expression models revealed crucial discrepancies in the outcomes observed in different models. Not only does the level of Ngb expression—either physiologically, overexpressed, or downregulated—alter its functional properties, the experimental setup, being in vitro or in vivo, does impact the functional outcome as well and, hence, whether or not a physiological and/or therapeutic role is ascribed to Ngb. These differences could highlight either technical or biological adaptations and should be considered until elucidation of the Ngb biology.
doi_str_mv 10.1155/2019/5728129
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subjects Animals
Brain
Hemoglobin
Hypoxia
Mammals
Metabolism
Mice, Transgenic
Nervous system
Neuroglobin - metabolism
Neurosciences
Physiology
Proteins
Review
Stem cells
title Neuroglobin Expression Models as a Tool to Study Its Function
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