Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy

Abstract MEGF10 myopathy is a rare inherited muscle disease that is named after the causative gene, MEGF10. The classic phenotype, early onset myopathy, areflexia, respiratory distress and dysphagia, is severe and immediately life-threatening. There are no disease-modifying therapies. We performed a...

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Veröffentlicht in:	Human molecular genetics 2019-07, Vol.28 (14), p.2365-2377
Hauptverfasser:	Saha, Madhurima, Rizzo, Skylar A, Ramanathan, Manashwi, Hightower, Rylie M, Santostefano, Katherine E, Terada, Naohiro, Finkel, Richard S, Berg, Jonathan S, Chahin, Nizar, Pacak, Christina A, Wagner, Richard E, Alexander, Matthew S, Draper, Isabelle, Kang, Peter B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Movement Cell Proliferation Citalopram - pharmacology Citalopram - therapeutic use Drosophila - drug effects Drosophila - genetics Drug Evaluation, Preclinical Humans Membrane Proteins - genetics Mice Mice, Knockout Muscle, Skeletal - metabolism Muscular Diseases - drug therapy Muscular Diseases - genetics Mutation Myoblasts - drug effects Myoblasts - metabolism Receptor, Notch1 - metabolism Serotonin Uptake Inhibitors - pharmacology Serotonin Uptake Inhibitors - therapeutic use Sertraline - pharmacology Sertraline - therapeutic use Signal Transduction Zebrafish - genetics Zebrafish - metabolism
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