Patronin-mediated minus end growth is required for dendritic microtubule polarity

Microtubule minus ends are thought to be stable in cells. Surprisingly, in and zebrafish neurons, we observed persistent minus end growth, with runs lasting over 10 min. In , extended minus end growth depended on Patronin, and Patronin reduction disrupted dendritic minus-end-out polarity. In fly den...

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Veröffentlicht in:	The Journal of cell biology 2019-07, Vol.218 (7), p.2309-2328
Hauptverfasser:	Feng, Chengye, Thyagarajan, Pankajam, Shorey, Matthew, Seebold, Dylan Y, Weiner, Alexis T, Albertson, Richard M, Rao, Kavitha S, Sagasti, Alvaro, Goetschius, Daniel J, Rolls, Melissa M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Polarity - genetics Dendrites Dendrites - genetics Dendritic structure Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila Proteins - genetics Embryo, Nonmammalian Embryonic Development - genetics Insects Kinesin - genetics Microtubule-Associated Proteins - genetics Microtubules Microtubules - genetics Neurons - metabolism Nucleation Polarity Reduction Regeneration Zebrafish
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