HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death

All neurodegenerative diseases are associated with oxidative stress-induced neuronal death. Forkhead box O3a (FOXO3a) is a key transcription factor involved in neuronal apoptosis. However, how FOXO3a forms complexes and functions in oxidative stress processing remains largely unknown. In the present...

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Veröffentlicht in:	The Journal of neuroscience 2015-01, Vol.35 (3), p.1250-1259
Hauptverfasser:	Peng, Shengyi, Zhao, Siqi, Yan, Feng, Cheng, Jinbo, Huang, Li, Chen, Hong, Liu, Qingsong, Ji, Xunming, Yuan, Zengqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Cerebellum - drug effects Cerebellum - metabolism Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Epigenesis, Genetic Forkhead Box Protein O3 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Histone Deacetylase 2 - genetics Histone Deacetylase 2 - metabolism Hydrogen Peroxide - pharmacology Mice Neurons - drug effects Neurons - metabolism Oxidative Stress - drug effects Oxidative Stress - physiology Phosphorylation Promoter Regions, Genetic Transcription, Genetic - physiology
Online-Zugang:	Volltext
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