Expression of ESR1 in Glutamatergic and GABAergic Neurons Is Essential for Normal Puberty Onset, Estrogen Feedback, and Fertility in Female Mice

Circulating estradiol exerts a profound influence on the activity of the gonadotropin-releasing hormone (GnRH) neuronal network controlling fertility. Using genetic strategies enabling neuron-specific deletion of estrogen receptor α (Esr1), we examine here whether estradiol-modulated GABA and glutam...

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Veröffentlicht in:	The Journal of neuroscience 2015-10, Vol.35 (43), p.14533-14543
Hauptverfasser:	Cheong, Rachel Y, Czieselsky, Katja, Porteous, Robert, Herbison, Allan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Estrogen Receptor alpha - biosynthesis Estrogen Receptor alpha - genetics Estrogen Receptor alpha - physiology Estrogens - physiology Estrous Cycle - genetics Estrous Cycle - physiology Feedback, Physiological - physiology Female Fertility - genetics Fertility - physiology Follicular Phase - genetics Follicular Phase - physiology gamma-Aminobutyric Acid - physiology Gene Knock-In Techniques Glutamates - physiology Gonadotropin-Releasing Hormone - metabolism Kisspeptins - metabolism Kisspeptins - physiology Limbic System - metabolism Mice Neurons - metabolism Prosencephalon - metabolism Sexual Maturation - genetics Sexual Maturation - physiology Vesicular Glutamate Transport Protein 2 - genetics Vesicular Glutamate Transport Protein 2 - physiology Vesicular Inhibitory Amino Acid Transport Proteins - genetics Vesicular Inhibitory Amino Acid Transport Proteins - metabolism
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