Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

Neuronal inclusions of hyperphosphorylated and aggregated tau protein are a pathological hallmark of several neurodegenerative tauopathies, including Alzheimer's disease (AD). The hypothesis of tau transmission in AD has emerged from histopathological studies of the spatial and temporal progres...

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Veröffentlicht in:	The Journal of neuroscience 2015-10, Vol.35 (42), p.14234-14250
Hauptverfasser:	Usenovic, Marija, Niroomand, Shahriar, Drolet, Robert E, Yao, Lihang, Gaspar, Renee C, Hatcher, Nathan G, Schachter, Joel, Renger, John J, Parmentier-Batteur, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Calcium - metabolism Cell Survival Cells, Cultured Enzyme-Linked Immunosorbent Assay Humans Induced Pluripotent Stem Cells - physiology Male Microfluidics Microscopy, Atomic Force Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurons - metabolism Neurotransmitter Agents - metabolism Phosphorylation Protein Transport - physiology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization tau Proteins - chemistry tau Proteins - metabolism tau Proteins - toxicity
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