mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain

Neuropathic pain is a common neurobiological disease involving multifaceted maladaptations ranging from gene modulation to synaptic dysfunction, but the interactions between synaptic dysfunction and the genes that are involved in persistent pain remain elusive. In the present study, we found that ne...

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Veröffentlicht in:	The Journal of neuroscience 2016-06, Vol.36 (23), p.6321-6331
Hauptverfasser:	Huang, Zhen-Zhen, Wei, Jia-You, Ou-Yang, Han-Dong, Li, Dai, Xu, Ting, Wu, Shao-Ling, Zhang, Xiao-Long, Liu, Cui-Cui, Ma, Chao, Xin, Wen-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - genetics Animals Antagomirs - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Disease Models, Animal Down-Regulation - genetics gamma-Aminobutyric Acid - metabolism Glutamate Decarboxylase - genetics Glutamate Decarboxylase - metabolism Hyperalgesia Inhibitory Postsynaptic Potentials - drug effects Inhibitory Postsynaptic Potentials - genetics Male MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Neuralgia - etiology Neuralgia - genetics Neuralgia - metabolism Paclitaxel - pharmacology Pain Threshold - drug effects Pain Threshold - physiology Posterior Horn Cells - drug effects Posterior Horn Cells - metabolism Rats Rats, Sprague-Dawley Rats, Transgenic Transcription Activator-Like Effector Nucleases - genetics Transcription Activator-Like Effector Nucleases - metabolism
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