Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity against this antigen. We isolated a panel of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2019-06, Vol.178 (1), p.216-228.e21
Hauptverfasser:	Alanine, Daniel G.W., Quinkert, Doris, Kumarasingha, Rasika, Mehmood, Shahid, Donnellan, Francesca R., Minkah, Nana K., Dadonaite, Bernadeta, Diouf, Ababacar, Galaway, Francis, Silk, Sarah E., Jamwal, Abhishek, Marshall, Jennifer M., Miura, Kazutoyo, Foquet, Lander, Elias, Sean C., Labbé, Geneviève M., Douglas, Alexander D., Jin, Jing, Payne, Ruth O., Illingworth, Joseph J., Pattinson, David J., Pulido, David, Williams, Barnabas G., de Jongh, Willem A., Wright, Gavin J., Kappe, Stefan H.I., Robinson, Carol V., Long, Carole A., Crabb, Brendan S., Gilson, Paul R., Higgins, Matthew K., Draper, Simon J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Antibodies, Monoclonal - immunology Antibodies, Neutralizing - immunology Antibodies, Protozoan - immunology Binding Sites blood-stage Carrier Proteins - immunology Cross Reactions - immunology Epitopes - immunology Erythrocytes - parasitology Female Healthy Volunteers HEK293 Cells Humans live-cell microscopy malaria Malaria Vaccines - immunology Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Male merozoite Merozoites - physiology Middle Aged monoclonal antibody neutralization Plasmodium falciparum - immunology Plasmodium falciparum - metabolism Protozoan Proteins - immunology Rabbits Rats Rats, Sprague-Dawley RH5 structural vaccinology synergy X-ray crystallography Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!