Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits

Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease characterized by left ventricular hypertrophy, diastolic dysfunction, and myocardial disarray. Disease onset occurs between 20 and 50 years of age, thus affecting patients in the prime of their life. HCM is caused by mutations in sarcome...

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Veröffentlicht in:	Antioxidants & redox signaling 2019-08, Vol.31 (4), p.318-358
Hauptverfasser:	Wijnker, Paul J M, Sequeira, Vasco, Kuster, Diederik W D, Velden, Jolanda van der
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animal models Animals Antioxidants Calcium - metabolism Cardiomyopathy Cardiomyopathy, Hypertrophic - genetics Cardiomyopathy, Hypertrophic - metabolism Cardiomyopathy, Hypertrophic - pathology Comprehensive Invited Reviews Coronary artery disease Deoxyribonucleic acid Depletion DNA Energy metabolism Epigenesis, Genetic - genetics Heart Heart diseases Humans Hypertrophy Lipids Metabolism Microvasculature Mitochondria Muscle contraction Mutation Oxidative stress Pharmacology Proteins Quality control Reactive oxygen species Reactive Oxygen Species - metabolism Sarcomeres - genetics Sarcomeres - metabolism Sarcomeres - pathology Ventricle
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