IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation

Leukemias exhibit a dysregulated developmental program mediated through both genetic and epigenetic mechanisms. Although IKZF2 is expressed in hematopoietic stem cells (HSCs), we found that it is dispensable for mouse and human HSC function. In contrast to its role as a tumor suppressor in hypodiplo...

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Veröffentlicht in:	Cell stem cell 2019-01, Vol.24 (1), p.153-165.e7
Hauptverfasser:	Park, Sun-Mi, Cho, Hyunwoo, Thornton, Angela M., Barlowe, Trevor S., Chou, Timothy, Chhangawala, Sagar, Fairchild, Lauren, Taggart, James, Chow, Arthur, Schurer, Alexandria, Gruet, Antoine, Witkin, Matthew D., Kim, Jun Hyun, Shevach, Ethan M., Krivtsov, Andrei, Armstrong, Scott A., Leslie, Christina, Kharas, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals C/EBP Cell Differentiation Cell Self Renewal Chromatin - genetics Chromatin - metabolism DNA-Binding Proteins - physiology Female Gene Expression Regulation, Leukemic Hematopoiesis HOXA9 IKZF2 Leukemia, Experimental - genetics Leukemia, Experimental - metabolism Leukemia, Experimental - pathology Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology leukemic stem cells Mice Mice, Inbred C57BL Mice, Knockout Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Transcription Factors - physiology
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