Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival

Mitochondria play an important role in the regulation of neurotransmission, and mitochondrial impairment is a key event in neurodegeneration. Cells rely on mitochondrial carrier proteins of the SLC25 family to shuttle ions, cofactors, and metabolites necessary for enzymatic reactions. Mutations in t...

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Veröffentlicht in:	The Journal of neuroscience 2016-02, Vol.36 (6), p.1914-1929
Hauptverfasser:	Slabbaert, Jan R, Kuenen, Sabine, Swerts, Jef, Maes, Ine, Uytterhoeven, Valerie, Kasprowicz, Jaroslaw, Fernandes, Ana Clara, Blust, Ronny, Verstreken, Patrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Cell Survival - genetics Drosophila Drosophila Proteins - genetics Drosophila Proteins - physiology Humans Larva - metabolism Membrane Potential, Mitochondrial - genetics Membrane Potential, Mitochondrial - physiology Metals - metabolism Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - physiology Mutation, Missense - genetics Neurons - physiology Neurotransmitter Agents - metabolism Patch-Clamp Techniques Synapses - physiology Synaptic Transmission - genetics
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