Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTPσ Synaptic Adhesion and Intracellular Signaling Pathways

Neurotrophin-3 (NT-3) is a secreted neurotrophic factor that binds neurotrophin receptor tyrosine kinase C (TrkC), which in turn binds to presynaptic protein tyrosine phosphatase σ (PTPσ) to govern excitatory synapse development. However, whether and how NT-3 cooperates with the TrkC-PTPσ synaptic a...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of neuroscience 2016-04, Vol.36 (17), p.4816-4831
Hauptverfasser:	Han, Kyung Ah, Woo, Doyeon, Kim, Seungjoon, Choii, Gayoung, Jeon, Sangmin, Won, Seoung Youn, Kim, Ho Min, Heo, Won Do, Um, Ji Won, Ko, Jaewon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - drug effects Cells, Cultured Extracellular Signal-Regulated MAP Kinases - metabolism Hippocampus Neurons - physiology Neurotrophin 3 - metabolism Protein Binding Rats Receptor, trkC - metabolism Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 2 - metabolism Signal Transduction - drug effects Synapses - metabolism Synapses - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!