From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses

The Old World monkey, Rhesus macaque (Macaca mulatta, Mm), is frequently used as a primate model organism in the study of human disease and to test new vaccines/antibody treatments despite diverging before chimpanzees and orangutans. Mm and humans share 93% genome identity with substantial differenc...

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Veröffentlicht in:	mAbs 2019-05, Vol.11 (4), p.709-724
Hauptverfasser:	Tolbert, William David, Subedi, Ganesh Prasad, Gohain, Neelakshi, Lewis, George Kenneth, Patel, Kashyap Rajesh, Barb, Adam Wesley, Pazgier, Marzena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Evolution Crystallization Crystallography, X-Ray Humans Immunoglobulin Fc Fragments - chemistry Immunoglobulin Fc Fragments - metabolism Immunoglobulin Isotypes - chemistry Immunoglobulin Isotypes - metabolism Macaca fascicularis Macaca mulatta Protein Binding Protein Conformation Receptors, IgG - metabolism Structure-Activity Relationship
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