Correlated protein conformational states and membrane dynamics during attack by pore-forming toxins

Pore-forming toxins (PFTs) are a class of proteins implicated in a wide range of virulent bacterial infections and diseases. These toxins bind to target membranes and subsequently oligomerize to form functional pores that eventually lead to cell lysis. While the protein undergoes large conformationa...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-06, Vol.116 (26), p.12839-12844
Hauptverfasser:	Ponmalar, Ilanila I, Cheerla, Ramesh, Ayappa, K Ganapathy, Basu, Jaydeep K
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Bacterial Toxins - chemistry Bacterial Toxins - pharmacology Biological Sciences Cell fusion Cell Membrane - chemistry Cell Membrane - drug effects Cholesterol Correlation analysis Coupling (molecular) Cytolysins Energy transfer Fluorescence Fluorescence Resonance Energy Transfer Fluorescence spectroscopy Food contamination Food poisoning Heat-Shock Proteins - chemistry Heat-Shock Proteins - pharmacology Hemolysin Proteins - chemistry Hemolysin Proteins - pharmacology Intermediates Kinetics Leakage Lipids Listeriolysin O Lysis Membrane proteins Membranes Molecular dynamics Molecular Dynamics Simulation Oligomerization Pore formation Protein Conformation Protein folding Protein interaction Proteins Toxins Unilamellar Liposomes - chemistry
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