Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs

Abdominal aortic aneurysm (AAA) remains the second most frequent vascular disease with high mortality but has no approved medical therapy. We investigated the direct role of apelin (APLN) in AAA and identified a unique approach to enhance APLN action as a therapeutic intervention for this disease. L...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-06, Vol.116 (26), p.13006-13015
Hauptverfasser:	Wang, Wang, Shen, Mengcheng, Fischer, Conrad, Basu, Ratnadeep, Hazra, Saugata, Couvineau, Pierre, Paul, Manish, Wang, Faqi, Toth, Sandra, Mix, Doran S., Poglitsch, Marko, Gerard, Norma P., Bouvier, Michel, Vederas, John C., Penninger, Josef M., Kassiri, Zamaneh, Oudit, Gavin Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Aged Aged, 80 and over Analogs Aneurysms Angiotensin Angiotensin II Angiotensin II - administration & dosage Angiotensin-converting enzyme 2 Animals Aorta Aorta, Abdominal - cytology Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - drug therapy Aortic Aneurysm, Abdominal - etiology Aortic Aneurysm, Abdominal - pathology Aortic aneurysms Apelin - genetics Apelin - metabolism Apoptosis Apoptosis - drug effects Apoptosis - genetics Biological Sciences Cardiovascular Agents - chemistry Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Diet, High-Fat - adverse effects Disease Models, Animal Endopeptidases Enzymes Female Gene Knockdown Techniques High fat diet Humans Hypertension Male Mice, Transgenic Middle Aged Muscles Myocytes, Smooth Muscle Neprilysin Neprilysin - genetics Neprilysin - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Peptidyl-Dipeptidase A - metabolism Pharmacology Phenylephrine Phenylephrine - administration & dosage PNAS Plus Primary Cell Culture Proteolysis - drug effects Receptors, LDL - genetics Receptors, LDL - metabolism Renin RNA, Small Interfering - metabolism Rupture Rupturing Smooth muscle Sympathomimetics Therapy Vascular diseases Vascular Remodeling - drug effects Vascular Remodeling - genetics
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