Insight of the Interaction between 2,4-thiazolidinedione and Human Serum Albumin: A Spectroscopic, Thermodynamic and Molecular Docking Study

Thiazolidinedione derivatives (TZDs) have attracted attention because of their pharmacological effects. For example, certain TZDs have been reported to ameliorate type II diabetes by binding and activating PPARs (peroxisome proliferator-activated receptors). Nonetheless, no information is available...

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Veröffentlicht in:	International journal of molecular sciences 2019-06, Vol.20 (11), p.2727
Hauptverfasser:	Rahman, Safikur, Rehman, Md Tabish, Rabbani, Gulam, Khan, Parvez, AlAjmi, Mohamed F, Hassan, Md Imtaiyaz, Muteeb, Ghazala, Kim, Jihoe
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Antidiabetics Binding Binding sites Biochemistry Calorimetry Cancer Chemical bonds Circular dichroism Conformation Diabetes Diabetes mellitus Dichroism Drugs Dynamic stability Enzyme kinetics Exothermic reactions Fluorescence Fluorescence spectroscopy Human serum albumin Hydrogen bonding Hydrogen bonds Kinases Ligands Molecular docking Molecular dynamics Peroxisome proliferator-activated receptors Pharmacodynamics Pharmacokinetics Pharmacology Proteins Serum albumin Stoichiometry Titration
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