Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the t...
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| Veröffentlicht in: | International journal of molecular sciences 2019-06, Vol.20 (11), p.2809 |
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| creator | Bouffard, Elise Mauriello Jimenez, Chiara El Cheikh, Khaled Maynadier, Marie Basile, Ilaria Raehm, Laurence Nguyen, Christophe Gary-Bobo, Magali Garcia, Marcel Durand, Jean-Olivier Morère, Alain |
| description | The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the targeting of the cation-independent mannose 6-phosphate receptor, which is overexpressed in prostate cancer. This original sugar, a dimannoside-carboxylate (M6C-Man) grafted on the surface of MSN for PDT applications, leads to a higher endocytosis and thus increases the efficacy of MSNs. |
| doi_str_mv | 10.3390/ijms20112809 |
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| ispartof | International journal of molecular sciences, 2019-06, Vol.20 (11), p.2809 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Cancer therapies Carbohydrates Cations Chemical Sciences Communication Endocytosis Insulin-like growth factors Lectins Ligands Mannose Nanoparticles Photodynamic therapy Prostate cancer Silica |
| title | Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor |
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