USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis

Hyperactivation of the canonical Wnt-signaling pathway is a prominent feature of a number of human malignancies. Transcriptional activation of this signaling cascade depends on the formation of the β-catenin–B-cell CLL/lymphoma 9 (BCL9)–pygopus (PYGO) family plant homeodomain finger 1 complex, yet h...

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Veröffentlicht in:	The Journal of biological chemistry 2019-06, Vol.294 (25), p.9844-9857
Hauptverfasser:	Shang, Zesen, Zhao, Jiao, Zhang, Qi, Cao, Cheng, Tian, Shanshan, Zhang, Kai, Liu, Ling, Shi, Lei, Yu, Na, Yang, Shangda
Format:	Artikel
Sprache:	eng
Schlagworte:	B-cell CLL/lymphoma 9 (BCL9) beta Catenin - genetics beta Catenin - metabolism breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology carcinogenesis Cell Biology Cell Movement Cell Proliferation cell signaling deubiquitylation (deubiquitination) Female Gene Expression Regulation, Neoplastic Humans Lys-63–linked polyubiquitins Proteolysis Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured Ubiquitin - metabolism Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism ubiquitin-specific peptidase 9, X-linked (USP9X) Wnt pathway Wnt1 Protein - genetics Wnt1 Protein - metabolism
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