Regulation of leukocyte function by citric acid cycle intermediates
Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle intermediates target vital cellular functions of the innate immune system. Succinate, itaconate, citrate, and fumarate have been shown to mediate or re...
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| Veröffentlicht in: | Journal of leukocyte biology 2019-07, Vol.106 (1), p.105-117 |
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| container_end_page | 117 |
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| container_title | Journal of leukocyte biology |
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| creator | Patil, Naeem K. Bohannon, Julia K. Hernandez, Antonio Patil, Tazeen K. Sherwood, Edward R. |
| description | Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle intermediates target vital cellular functions of the innate immune system. Succinate, itaconate, citrate, and fumarate have been shown to mediate or regulate important myeloid cell functions during infection and inflammation. This review covers the regulatory functions of citric acid cycle intermediates in myeloid cells and discusses potential translational applications, key mechanistic questions, and future research directions.
This review outlines current understanding of inflammation‐induced alterations in leukocyte metabolism and implications for leukocyte function and novel therapeutic development.
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| doi_str_mv | 10.1002/JLB.3MIR1118-415R |
| format | Article |
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This review outlines current understanding of inflammation‐induced alterations in leukocyte metabolism and implications for leukocyte function and novel therapeutic development.
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This review outlines current understanding of inflammation‐induced alterations in leukocyte metabolism and implications for leukocyte function and novel therapeutic development.
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This review outlines current understanding of inflammation‐induced alterations in leukocyte metabolism and implications for leukocyte function and novel therapeutic development.
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| identifier | ISSN: 0741-5400 |
| ispartof | Journal of leukocyte biology, 2019-07, Vol.106 (1), p.105-117 |
| issn | 0741-5400 1938-3673 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals citrate Citric Acid - pharmacology Citric Acid Cycle - physiology fumarate Fumarates - pharmacology Humans itaconate Leukocytes - physiology metabolic reprogramming Reactive Oxygen Species - metabolism succinate Succinates - pharmacology Succinic Acid - pharmacology |
| title | Regulation of leukocyte function by citric acid cycle intermediates |
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