Overdominant Effect of a CHRNA4 Polymorphism on Cingulo-Opercular Network Activity and Cognitive Control

The nicotinic system plays an important role in cognitive control and is implicated in several neuropsychiatric conditions. However, the contributions of genetic variability in this system to individuals' cognitive control abilities are poorly understood and the brain processes that mediate suc...

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Veröffentlicht in:	The Journal of neuroscience 2017-10, Vol.37 (40), p.9657-9666
Hauptverfasser:	Sadaghiani, Sepideh, Ng, Bernard, Altmann, Andre, Poline, Jean-Baptiste, Banaschewski, Tobias, Bokde, Arun L W, Bromberg, Uli, Büchel, Christian, Burke Quinlan, Erin, Conrod, Patricia, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Gallinat, Jürgen, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Lemaitre, Hervé, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H, Smolka, Michael N, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Napolioni, Valerio, Greicius, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alertness Brain Brain mapping Cerebral Cortex - physiology Cognition - physiology Cognitive ability Cohort Studies Control systems Cortex Female Females Frontal Lobe - physiology Functional magnetic resonance imaging Gene polymorphism Genetic Association Studies - methods Genetic variability Genetics Gyrus Cinguli - physiology Haplotypes Heterozygotes Homozygotes Humans Magnetic Resonance Imaging - methods Male Males Medical imaging Microprocessors Nerve Net - physiology Neuroimaging Neurology Nicotine Photic Stimulation - methods Polymorphism Polymorphism, Single Nucleotide - genetics Psychomotor Performance - physiology Quantitative trait loci Receptors, Nicotinic - genetics
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