Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation

Cerebellar granule cell precursors (GCPs) and granule cells (GCs) represent good models to study neuronal development. Here, we report that the transcription factor myeloid ectopic viral integration site 1 homolog (Meis1) plays pivotal roles in the regulation of mouse GC development. We found that M...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2018-01, Vol.38 (5), p.1277-1294
Hauptverfasser:	Owa, Tomoo, Taya, Shinichiro, Miyashita, Satoshi, Yamashita, Mariko, Adachi, Toma, Yamada, Koyo, Yokoyama, Miwa, Aida, Shogo, Nishioka, Tomoki, Inoue, Yukiko U, Goitsuka, Ryo, Nakamura, Takuro, Inoue, Takayoshi, Kaibuchi, Kozo, Hoshino, Mikio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Astrocytes Astrocytes - metabolism Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - physiology Bone morphogenetic proteins Bone Morphogenetic Proteins - biosynthesis Bone Morphogenetic Proteins - genetics Cell Cycle - genetics Cell Cycle - physiology Cell Differentiation - genetics Cell Differentiation - physiology Cell signaling Cerebellum Cerebellum - cytology Cerebellum - growth & development Cytoplasmic Granules Degradation Differentiation Female Granular materials Granule cells Homology Male Math1 protein MEIS1 gene Mice Mice, Inbred ICR Mice, Knockout Molecular machines Morphology Myeloid Ecotropic Viral Integration Site 1 Protein - physiology Neural stem cells Pax6 protein PAX6 Transcription Factor - biosynthesis PAX6 Transcription Factor - genetics Phosphorylation Pregnancy Proteins Signal Transduction - genetics Signal Transduction - physiology Signaling Smad protein Smad Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!