Conditional Deletion of Hippocampal CA2/CA3a Oxytocin Receptors Impairs the Persistence of Long-Term Social Recognition Memory in Mice

Oxytocin (OXT) receptors (OXTRs) are prominently expressed in hippocampal CA2 and CA3 pyramidal neurons, but little is known about its physiological function. As the functional necessity of hippocampal CA2 for social memory processing, we tested whether CA2 OXTRs may contribute to long-term social r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2018-01, Vol.38 (5), p.1218-1231
Hauptverfasser:	Lin, Yu-Ting, Hsieh, Tsan-Yu, Tsai, Tsung-Chih, Chen, Chien-Chung, Huang, Chiung-Chun, Hsu, Kuei-Sen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety CA2 Region, Hippocampal - cytology CA2 Region, Hippocampal - metabolism CA2 Region, Hippocampal - physiology Ca2+/calmodulin-dependent protein kinase II CA3 Region, Hippocampal - cytology CA3 Region, Hippocampal - metabolism CA3 Region, Hippocampal - physiology Calcium Calcium-binding protein Calmodulin Cortex (entorhinal) Dendrites - drug effects Dendrites - ultrastructure Dendritic spines Entorhinal Cortex - cytology Entorhinal Cortex - metabolism Entorhinal Cortex - physiology Excitatory Postsynaptic Potentials - drug effects Feeding behavior Forebrain Gene Deletion Glutamic acid receptors Hippocampus Kinases Long-term depression Long-term potentiation Long-Term Potentiation - genetics Male Memory, Short-Term - physiology Mice Mice, Inbred C57BL Mice, Knockout N-Methyl-D-aspartic acid receptors Neurons Neurons - physiology Open-field behavior Oxytocin Oxytocin - analogs & derivatives Oxytocin - pharmacology Oxytocin receptors Proteins Pyramidal cells Pyramidal Cells - drug effects Pyramidal Cells - ultrastructure Receptor mechanisms Receptors Receptors, N-Methyl-D-Aspartate - agonists Receptors, Oxytocin - agonists Receptors, Oxytocin - genetics Receptors, Oxytocin - physiology Recognition Recognition (Psychology) - physiology Rodents Social Behavior Social interactions Synapses Synaptic depression
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!