Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein

Monoclonal antibody (mAb) cooperativity is a phenomenon triggered when mAbs couples promote increased bactericidal killing compared to individual partners. Cooperativity has been deeply investigated among mAbs elicited by factor H-binding protein (fHbp), a Neisseria meningitidis surface-exposed lipo...

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Veröffentlicht in:	Communications biology 2019-06, Vol.2 (1), p.241-241, Article 241
Hauptverfasser:	Peschiera, Ilaria, Giuliani, Maria, Giusti, Fabiola, Melero, Roberto, Paccagnini, Eugenio, Donnarumma, Danilo, Pansegrau, Werner, Carazo, José M., Sorzano, Carlos O. S., Scarselli, Maria, Masignani, Vega, Liljeroos, Lassi J., Ferlenghi, Ilaria
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 101/28 101/58 631/45/535/1258/1259 631/535/1258/1260 692/699/255/1638 82/83 Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antigens Antigens, Bacterial - immunology Bacterial Proteins - immunology Biology Biomedical and Life Sciences Blood Bactericidal Activity Complement Factor H - metabolism Cooperativity Electron microscopy Epitope Mapping Epitopes Factor H-binding protein H protein Humans Life Sciences Meningococcal Vaccines - immunology Microscopy, Electron, Transmission Monoclonal antibodies Proteins Structure-function relationships Surface Plasmon Resonance Vaccine efficacy Vaccines
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