Roles of circular RNAs in immune regulation and autoimmune diseases
Circular RNAs (circRNAs), as a novel class of endogenously expressed non-coding RNAs (ncRNAs), have a high stability and often present tissue-specific expression and evolutionary conservation. Emerging evidence has suggested that circRNAs play an essential role in complex human pathologies. Notably,...
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| Veröffentlicht in: | Cell death & disease 2019-06, Vol.10 (7), p.503-13, Article 503 |
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| description | Circular RNAs (circRNAs), as a novel class of endogenously expressed non-coding RNAs (ncRNAs), have a high stability and often present tissue-specific expression and evolutionary conservation. Emerging evidence has suggested that circRNAs play an essential role in complex human pathologies. Notably, circRNAs, important gene modulators in the immune system, are strongly associated with the occurrence and development of autoimmune diseases. Here, we focus on the roles of circRNAs in immune cells and immune regulation, highlighting their potential as biomarkers and biological functions in autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary biliary cholangitis (PBC), and psoriasis, aiming at providing new insights into the diagnosis and therapy of these diseases. |
| doi_str_mv | 10.1038/s41419-019-1744-5 |
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Emerging evidence has suggested that circRNAs play an essential role in complex human pathologies. Notably, circRNAs, important gene modulators in the immune system, are strongly associated with the occurrence and development of autoimmune diseases. Here, we focus on the roles of circRNAs in immune cells and immune regulation, highlighting their potential as biomarkers and biological functions in autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary biliary cholangitis (PBC), and psoriasis, aiming at providing new insights into the diagnosis and therapy of these diseases.</description><identifier>ISSN: 2041-4889</identifier><identifier>EISSN: 2041-4889</identifier><identifier>DOI: 10.1038/s41419-019-1744-5</identifier><identifier>PMID: 31243263</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/38 ; 692/420/2780 ; Animals ; Antibodies ; Autoimmune diseases ; Autoimmune Diseases - genetics ; Autoimmune Diseases - immunology ; Autoimmune Diseases - metabolism ; Autoimmunity - genetics ; Autoimmunity - immunology ; Autoimmunity - physiology ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cell Culture ; Cholangitis ; Evolutionary conservation ; Humans ; Immune system ; Immunology ; Immunoregulation ; Life Sciences ; Liver Cirrhosis, Biliary - genetics ; Liver Cirrhosis, Biliary - immunology ; Liver Cirrhosis, Biliary - metabolism ; Lupus Erythematosus, Systemic - genetics ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - metabolism ; Multiple sclerosis ; Multiple Sclerosis - genetics ; Multiple Sclerosis - immunology ; Multiple Sclerosis - metabolism ; Psoriasis ; Psoriasis - genetics ; Psoriasis - immunology ; Psoriasis - metabolism ; Review ; Review Article ; Rheumatoid arthritis ; RNA, Circular - genetics ; RNA, Circular - physiology ; Systemic lupus erythematosus</subject><ispartof>Cell death & disease, 2019-06, Vol.10 (7), p.503-13, Article 503</ispartof><rights>The Author(s) 2019</rights><rights>2019. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell death & disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Zheng</au><au>Sun, Bao</au><au>Huang, Shiqiong</au><au>Zhao, Lingling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roles of circular RNAs in immune regulation and autoimmune diseases</atitle><jtitle>Cell death & disease</jtitle><stitle>Cell Death Dis</stitle><addtitle>Cell Death Dis</addtitle><date>2019-06-26</date><risdate>2019</risdate><volume>10</volume><issue>7</issue><spage>503</spage><epage>13</epage><pages>503-13</pages><artnum>503</artnum><issn>2041-4889</issn><eissn>2041-4889</eissn><abstract>Circular RNAs (circRNAs), as a novel class of endogenously expressed non-coding RNAs (ncRNAs), have a high stability and often present tissue-specific expression and evolutionary conservation. Emerging evidence has suggested that circRNAs play an essential role in complex human pathologies. Notably, circRNAs, important gene modulators in the immune system, are strongly associated with the occurrence and development of autoimmune diseases. Here, we focus on the roles of circRNAs in immune cells and immune regulation, highlighting their potential as biomarkers and biological functions in autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary biliary cholangitis (PBC), and psoriasis, aiming at providing new insights into the diagnosis and therapy of these diseases.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31243263</pmid><doi>10.1038/s41419-019-1744-5</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4118-1691</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/250/38 692/420/2780 Animals Antibodies Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmunity - genetics Autoimmunity - immunology Autoimmunity - physiology Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cholangitis Evolutionary conservation Humans Immune system Immunology Immunoregulation Life Sciences Liver Cirrhosis, Biliary - genetics Liver Cirrhosis, Biliary - immunology Liver Cirrhosis, Biliary - metabolism Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Psoriasis Psoriasis - genetics Psoriasis - immunology Psoriasis - metabolism Review Review Article Rheumatoid arthritis RNA, Circular - genetics RNA, Circular - physiology Systemic lupus erythematosus |
| title | Roles of circular RNAs in immune regulation and autoimmune diseases |
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