Kinetic analysis of transcellular passage of the cobalamin-transcobalamin complex in Caco-2 monolayers

We suggest a novel kinetic approach to quantifying receptor-ligand interactions via the cellular transport and/or accumulation of the ligand. The system of cobalamin (Cbl, vitamin B12) transport was used as a model, because Cbl is an obligatory cofactor, taken up by animal cells with the help of a t...

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Veröffentlicht in:	Molecular biology of the cell 2019-02, Vol.30 (4), p.467-477
Hauptverfasser:	Juul, Christian B, Fedosov, Sergey N, Nexo, Ebba, Heegaard, Christian W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Caco-2 Cells Cattle Cobalt Radioisotopes Humans Kinetics Ligands Receptors, Cell Surface - metabolism Transcobalamins - metabolism Vitamin B 12 - metabolism
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