Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity

Innate lymphoid cells (ILC) play critical roles in regulating immunity, inflammation, and tissue homeostasis in mice. However, limited access to non-diseased human tissues has hindered efforts to profile anatomically-distinct ILCs in humans. Through flow cytometric and transcriptional analyses of ly...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2019-02, Vol.50 (2), p.505-519.e4
Hauptverfasser:	Yudanin, Naomi A., Schmitz, Frederike, Flamar, Anne-Laure, Thome, Joseph J.C., Tait Wojno, Elia, Moeller, Jesper B., Schirmer, Melanie, Latorre, Isabel J., Xavier, Ramnik J., Farber, Donna L., Monticelli, Laurel A., Artis, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aging Aging - genetics Animal tissues Animals Child Child, Preschool Cytokines Female Flow cytometry Genetic Heterogeneity Heterogeneity Homeostasis Human tissues Humans Immunity Immunity, Innate - genetics Immunity, Innate - immunology Infant Infant, Newborn Inflammation Inflammatory bowel disease Localization Lymphatic system Lymphocytes Lymphocytes - immunology Lymphocytes - metabolism Lymphoid cells Male Mapping Metabolism Mice Middle Aged Mucosa Organ donors Organ Specificity - genetics Organ Specificity - immunology Software Transcription Transcriptome - genetics Transcriptome - immunology Young Adult
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