Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions

It has been demonstrated that divalent zinc ions packaged with insulin in β-cell granules can be detected by MRI during glucose-stimulated insulin secretion using a gadolinium-based Zn2+-sensitive agent. This study was designed to evaluate whether a simpler agent design having single Zn2+-sensing mo...

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Veröffentlicht in:	Journal of the American Chemical Society 2018-12, Vol.140 (50), p.17456-17464
Hauptverfasser:	Martins, André F, Clavijo Jordan, Veronica, Bochner, Filip, Chirayil, Sara, Paranawithana, Namini, Zhang, Shanrong, Lo, Su-Tang, Wen, Xiaodong, Zhao, Piyu, Neeman, Michal, Sherry, A. Dean
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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