Coculture with monocytes/macrophages modulates osteogenic differentiation of adipose‐derived mesenchymal stromal cells on poly(lactic‐co‐glycolic) acid/polycaprolactone scaffolds

The effects of immune cells, in particular macrophages, on the behaviour of mesenchymal stromal cells (MSCs) have recently gained much attention for MSCs‐based tissue‐engineered constructs. This study aimed to evaluate the effect of monocytes/macrophages on the osteogenic differentiation of adipose‐...

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Veröffentlicht in:	Journal of tissue engineering and regenerative medicine 2019-05, Vol.13 (5), p.785-798
Hauptverfasser:	Tang, Hongbo, Husch, Johanna F.A., Zhang, Yang, Jansen, John A., Yang, Fang, Beucken, Jeroen J.J.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adipose Tissue - cytology Adipose Tissue - metabolism adipose‐derived mesenchymal stromal cells Alkaline phosphatase Biocompatibility Bone healing Bone morphogenetic protein 2 Bone sialoprotein Cbfa-1 protein Cell Differentiation coculture Coculture Techniques Differentiation (biology) Humans Immune system Macrophages Macrophages - cytology Macrophages - metabolism Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Monocytes Monocytes - cytology Monocytes - metabolism Oncostatin M Osteogenesis osteogenic differentiation Polycaprolactone Polyesters - chemistry Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polylactide-co-glycolide Regenerative medicine Scaffolds Stromal cells THP-1 Cells Tissue engineering Tissue Scaffolds - chemistry
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