Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange

A general approach for the efficient hydrogen‐isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D2 or T2 as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolerabili...

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Veröffentlicht in:	Angewandte Chemie International Edition 2019-04, Vol.58 (15), p.4891-4895
Hauptverfasser:	Palazzolo, Alberto, Feuillastre, Sophie, Pfeifer, Viktor, Garcia‐Argote, Sébastien, Bouzouita, Donia, Tricard, Simon, Chollet, Céline, Marcon, Elodie, Buisson, David‐Alexandre, Cholet, Sophie, Fenaille, François, Lippens, Guy, Chaudret, Bruno, Pieters, Grégory
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Chromatography, Liquid Communication Communications C−H activation Deuteration Deuterium - chemistry Deuterium Exchange Measurement Diagnostic software Diagnostic systems Drug discovery Drugs Exchanging Hydrogen - chemistry isotopes isotopic labelling Mass Spectrometry Nanoparticles nucleotides Oligonucleotides Oligonucleotides - chemistry Pharmaceutical Preparations - chemistry Pharmaceuticals Ruthenium Substrates
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