Exosomal Interferon‐Induced Transmembrane Protein 2 Transmitted to Dendritic Cells Inhibits Interferon Alpha Pathway Activation and Blocks Anti–Hepatitis B Virus Efficacy of Exogenous Interferon Alpha

The negative regulators in the interferon (IFN) signaling pathway inhibit intrahepatic immune response, resulting in suboptimal therapeutic response to IFNα treatment in chronic hepatitis B (CHB) patients. Identifying the key negative factors and elucidating the regulating mechanism are essential fo...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2019-06, Vol.69 (6), p.2396-2413
Hauptverfasser:	Shi, Ying, Du, Lingyao, Lv, Duoduo, Li, Hong, Shang, Jin, Lu, Jiajie, Zhou, Lingyun, Bai, Lang, Tang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell activation Dendritic cells Exosomes Extracellular signal-regulated kinase Gene expression Hepatitis Hepatitis B Hepatology Immune status Interferon Interferon regulatory factor Interferon regulatory factor 3 Kinases Leukocytes (mononuclear) Original Palmitoylation Peripheral blood mononuclear cells Phosphorylation Proteins Signal transduction Transmembrane proteins α-Interferon
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