EGF receptor (EGFR) inhibition promotes a slow-twitch oxidative, over a fast-twitch, muscle phenotype

A low quadriceps slow-twitch (ST), oxidative (relative to fast-twitch) fiber proportion is prevalent in chronic diseases such Chronic Obstructive Pulmonary Disease (COPD) and is associated with exercise limitation and poor outcomes. Benefits of an increased ST fiber proportion are demonstrated in ge...

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Veröffentlicht in:	Scientific reports 2019-06, Vol.9 (1), p.9218-9, Article 9218
Hauptverfasser:	Ciano, Margherita, Mantellato, Giada, Connolly, Martin, Paul-Clark, Mark, Willis-Owen, Saffron, Moffatt, Miriam F., Cookson, William O. C. M., Mitchell, Jane A., Polkey, Michael I., Hughes, Simon M., Kemp, Paul R., Natanek, S. Amanda
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 42 42/109 42/89 45 45/61 45/77 631/443 64/116 692/699 Aged Animals Case-Control Studies Chronic obstructive pulmonary disease Danio rerio DNA microarrays Embryos Epidermal Growth Factor - genetics Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors Female Genome editing Genomes Genotype & phenotype Humanities and Social Sciences Humans Locomotion - drug effects Locomotion - physiology Lung diseases Male Mice Middle Aged Mitochondria multidisciplinary Muscle Fibers, Fast-Twitch - drug effects Muscle Fibers, Fast-Twitch - metabolism Muscle Fibers, Fast-Twitch - physiology Muscle Fibers, Slow-Twitch - drug effects Muscle Fibers, Slow-Twitch - metabolism Muscle Fibers, Slow-Twitch - physiology Myotubes Obstructive lung disease Oxidation-Reduction - drug effects Phenotype Phenotypes Protein Kinase Inhibitors - pharmacology Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - physiopathology Quadriceps muscle Ribonucleic acid RNA RNA, Messenger - genetics RNA-mediated interference Science Science (multidisciplinary) Transcription Zebrafish
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