CD163+ immune cell infiltrates and presence of CD54+ microvessels are prognostic markers for patients with embryonal rhabdomyosarcoma

Rhabdomyosarcomas (RMS) are rare and often lethal diseases. It is assumed that the tumor microenvironment (TME) of RMS exerts an immunosuppressive function, but there is currently no systematic analysis of the immune cells infiltrating sarcoma tissue. Focusing on two common types of RMS (alveolar [R...

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Veröffentlicht in:	Scientific reports 2019-06, Vol.9 (1), p.9211-12, Article 9211
Hauptverfasser:	Kather, Jakob Nikolas, Hörner, Christian, Weis, Cleo-Aron, Aung, Thiha, Vokuhl, Christian, Weiss, Christel, Scheer, Monika, Marx, Alexander, Simon-Keller, Katja
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/51 14 14/63 692/4028/67/327 692/53/2423 Alveoli Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism B7-H1 Antigen - metabolism Biomarkers, Tumor - metabolism Biopsy CD163 antigen Humanities and Social Sciences Humans Immunotherapy Infiltration Lymphocytes Macrophages Metastases Microvasculature Microvessels - immunology Microvessels - metabolism multidisciplinary Pathology Prognosis Programmed Cell Death 1 Receptor - metabolism Receptors, Cell Surface - metabolism Rhabdomyosarcoma Rhabdomyosarcoma, Embryonal - diagnosis Rhabdomyosarcoma, Embryonal - immunology Rhabdomyosarcoma, Embryonal - metabolism Rhabdomyosarcoma, Embryonal - pathology Sarcoma Science Science (multidisciplinary) Solid tumors Tumor-infiltrating lymphocytes Tumors
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