The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Key Points Poly(ADP-ribose) polymerase 1 (PARP1) was the first member of the PARP family to be identified. The PARP family now comprises 18 members. PARP1 post-translationally modifies itself and a range of other proteins that have diverse roles in different cellular processes. The catalytic activit...
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| Veröffentlicht in: | Nature reviews. Molecular cell biology 2017-10, Vol.18 (10), p.610-621 |
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| creator | Ray Chaudhuri, Arnab Nussenzweig, André |
| description | Key Points
Poly(ADP-ribose) polymerase 1 (PARP1) was the first member of the PARP family to be identified. The PARP family now comprises 18 members.
PARP1 post-translationally modifies itself and a range of other proteins that have diverse roles in different cellular processes.
The catalytic activity of PARP1 is responsible for mediating multiple DNA damage repair pathways.
PARP1 has a crucial role in the stabilization of DNA replication forks.
The role of PARP1 in remodelling chromatin overlaps with its role in DNA repair.
PARP1 inhibition is an attractive strategy for the treatment of cancers that are deficient in the repair of DNA double-strand breaks by homologous recombination.
Recent insights into the roles of poly(ADP-ribose) polymerase 1 (PARP1) in mediating various DNA repair pathways, stabilizing DNA replication and modulating chromatin structure are being exploited clinically for the treatment of DNA repair-deficient cancers.
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the maintenance of genomic stability. The inhibition of PARP1 is therefore being exploited clinically for the treatment of various cancers, which include DNA repair-deficient ovarian, breast and prostate cancers. Understanding the role of PARP1 in maintaining genome integrity is not only important for the design of novel chemotherapeutic agents, but is also crucial for gaining insights into the mechanisms of chemoresistance in cancer cells. In this Review, we discuss the roles of PARP1 in mediating various aspects of DNA metabolism, such as single-strand break repair, nucleotide excision repair, double-strand break repair and the stabilization of replication forks, and in modulating chromatin structure. |
| doi_str_mv | 10.1038/nrm.2017.53 |
| format | Article |
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Poly(ADP-ribose) polymerase 1 (PARP1) was the first member of the PARP family to be identified. The PARP family now comprises 18 members.
PARP1 post-translationally modifies itself and a range of other proteins that have diverse roles in different cellular processes.
The catalytic activity of PARP1 is responsible for mediating multiple DNA damage repair pathways.
PARP1 has a crucial role in the stabilization of DNA replication forks.
The role of PARP1 in remodelling chromatin overlaps with its role in DNA repair.
PARP1 inhibition is an attractive strategy for the treatment of cancers that are deficient in the repair of DNA double-strand breaks by homologous recombination.
Recent insights into the roles of poly(ADP-ribose) polymerase 1 (PARP1) in mediating various DNA repair pathways, stabilizing DNA replication and modulating chromatin structure are being exploited clinically for the treatment of DNA repair-deficient cancers.
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the maintenance of genomic stability. The inhibition of PARP1 is therefore being exploited clinically for the treatment of various cancers, which include DNA repair-deficient ovarian, breast and prostate cancers. Understanding the role of PARP1 in maintaining genome integrity is not only important for the design of novel chemotherapeutic agents, but is also crucial for gaining insights into the mechanisms of chemoresistance in cancer cells. In this Review, we discuss the roles of PARP1 in mediating various aspects of DNA metabolism, such as single-strand break repair, nucleotide excision repair, double-strand break repair and the stabilization of replication forks, and in modulating chromatin structure.</description><identifier>ISSN: 1471-0072</identifier><identifier>EISSN: 1471-0080</identifier><identifier>DOI: 10.1038/nrm.2017.53</identifier><identifier>PMID: 28676700</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337/1427/2566 ; 631/337/151 ; 631/67/1059/99 ; Adenosine diphosphate ; Animals ; Biochemistry ; Cancer ; Cancer Research ; Care and treatment ; Cell Biology ; Chemoresistance ; Chemotherapy ; Chromatin ; Chromatin Assembly and Disassembly ; Chromatin remodeling ; Deoxyribonucleic acid ; Developmental Biology ; DNA ; DNA Damage ; DNA Repair ; DNA Replication ; Double-strand break repair ; Genetic recombination ; Genomes ; Health aspects ; Humans ; Innovations ; Integrity ; Life Sciences ; Metabolism ; Molecular targeted therapy ; Nucleotide excision repair ; Poly (ADP-Ribose) Polymerase-1 - metabolism ; Poly(ADP-ribose) ; Poly(ADP-ribose) polymerase ; Properties ; Prostate ; Prostate cancer ; Repair ; Replication forks ; review-article ; Ribose ; Stem Cells ; Transferases</subject><ispartof>Nature reviews. Molecular cell biology, 2017-10, Vol.18 (10), p.610-621</ispartof><rights>Springer Nature Limited 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-99848b9a23d7d730bc6efa4f0c6ab9696091db82e00d0265c7999ce815cef43b3</citedby><cites>FETCH-LOGICAL-c547t-99848b9a23d7d730bc6efa4f0c6ab9696091db82e00d0265c7999ce815cef43b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nrm.2017.53$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nrm.2017.53$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28676700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ray Chaudhuri, Arnab</creatorcontrib><creatorcontrib>Nussenzweig, André</creatorcontrib><title>The multifaceted roles of PARP1 in DNA repair and chromatin remodelling</title><title>Nature reviews. Molecular cell biology</title><addtitle>Nat Rev Mol Cell Biol</addtitle><addtitle>Nat Rev Mol Cell Biol</addtitle><description>Key Points
Poly(ADP-ribose) polymerase 1 (PARP1) was the first member of the PARP family to be identified. The PARP family now comprises 18 members.
PARP1 post-translationally modifies itself and a range of other proteins that have diverse roles in different cellular processes.
The catalytic activity of PARP1 is responsible for mediating multiple DNA damage repair pathways.
PARP1 has a crucial role in the stabilization of DNA replication forks.
The role of PARP1 in remodelling chromatin overlaps with its role in DNA repair.
PARP1 inhibition is an attractive strategy for the treatment of cancers that are deficient in the repair of DNA double-strand breaks by homologous recombination.
Recent insights into the roles of poly(ADP-ribose) polymerase 1 (PARP1) in mediating various DNA repair pathways, stabilizing DNA replication and modulating chromatin structure are being exploited clinically for the treatment of DNA repair-deficient cancers.
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the maintenance of genomic stability. The inhibition of PARP1 is therefore being exploited clinically for the treatment of various cancers, which include DNA repair-deficient ovarian, breast and prostate cancers. Understanding the role of PARP1 in maintaining genome integrity is not only important for the design of novel chemotherapeutic agents, but is also crucial for gaining insights into the mechanisms of chemoresistance in cancer cells. In this Review, we discuss the roles of PARP1 in mediating various aspects of DNA metabolism, such as single-strand break repair, nucleotide excision repair, double-strand break repair and the stabilization of replication forks, and in modulating chromatin structure.</description><subject>631/337/1427/2566</subject><subject>631/337/151</subject><subject>631/67/1059/99</subject><subject>Adenosine diphosphate</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Cell Biology</subject><subject>Chemoresistance</subject><subject>Chemotherapy</subject><subject>Chromatin</subject><subject>Chromatin Assembly and Disassembly</subject><subject>Chromatin remodeling</subject><subject>Deoxyribonucleic acid</subject><subject>Developmental Biology</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>DNA Repair</subject><subject>DNA Replication</subject><subject>Double-strand break repair</subject><subject>Genetic recombination</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Innovations</subject><subject>Integrity</subject><subject>Life Sciences</subject><subject>Metabolism</subject><subject>Molecular targeted therapy</subject><subject>Nucleotide excision repair</subject><subject>Poly (ADP-Ribose) Polymerase-1 - metabolism</subject><subject>Poly(ADP-ribose)</subject><subject>Poly(ADP-ribose) polymerase</subject><subject>Properties</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Repair</subject><subject>Replication forks</subject><subject>review-article</subject><subject>Ribose</subject><subject>Stem Cells</subject><subject>Transferases</subject><issn>1471-0072</issn><issn>1471-0080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptks1v1DAQxSMEoqVw4o4icQHBLuPEnxekVYFSqYKqlLPlOJOsq8Re7ATBf49XW5Yuqnyw5fnNG73RK4rnBJYEavnOx3FZARFLVj8ojgkVZAEg4eH-Laqj4klKNwCEE8EeF0eV5IILgOPi7HqN5TgPk-uMxQnbMoYBUxm68nJ1dUlK58sPX1ZlxI1xsTS-Le06htFMuRBxDC0Og_P90-JRZ4aEz27vk-L7p4_Xp58XF1_Pzk9XFwvLqJgWSkkqG2WquhWtqKGxHDtDO7DcNIorDoq0jawQoIWKMyuUUhYlYRY7Wjf1SfF-p7uZmxFbi36KZtCb6EYTf-tgnD6seLfWffipOVNEVDILvLoViOHHjGnSo0s2mzAew5w0UYTXMq-JZfTlf-hNmKPP9jJFBVAqFP1H9WZA7XwX8ly7FdUrBoxnG3w7dnkPlU-Lo7PBY-fy_0HD64OGzEz4a-rNnJI-_3Z1yL7ZsTaGlCJ2-30Q0NuM6JwRvc2IZnWmX9xd4Z79G4oMvN0BKZd8j_GO73v0_gADl8K9</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Ray Chaudhuri, Arnab</creator><creator>Nussenzweig, André</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171001</creationdate><title>The multifaceted roles of PARP1 in DNA repair and chromatin remodelling</title><author>Ray Chaudhuri, Arnab ; Nussenzweig, André</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-99848b9a23d7d730bc6efa4f0c6ab9696091db82e00d0265c7999ce815cef43b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/337/1427/2566</topic><topic>631/337/151</topic><topic>631/67/1059/99</topic><topic>Adenosine diphosphate</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Cell Biology</topic><topic>Chemoresistance</topic><topic>Chemotherapy</topic><topic>Chromatin</topic><topic>Chromatin Assembly and Disassembly</topic><topic>Chromatin remodeling</topic><topic>Deoxyribonucleic acid</topic><topic>Developmental Biology</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>DNA Repair</topic><topic>DNA Replication</topic><topic>Double-strand break repair</topic><topic>Genetic recombination</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Innovations</topic><topic>Integrity</topic><topic>Life Sciences</topic><topic>Metabolism</topic><topic>Molecular targeted therapy</topic><topic>Nucleotide excision repair</topic><topic>Poly (ADP-Ribose) Polymerase-1 - metabolism</topic><topic>Poly(ADP-ribose)</topic><topic>Poly(ADP-ribose) polymerase</topic><topic>Properties</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Repair</topic><topic>Replication forks</topic><topic>review-article</topic><topic>Ribose</topic><topic>Stem Cells</topic><topic>Transferases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ray Chaudhuri, Arnab</creatorcontrib><creatorcontrib>Nussenzweig, André</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature reviews. Molecular cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ray Chaudhuri, Arnab</au><au>Nussenzweig, André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The multifaceted roles of PARP1 in DNA repair and chromatin remodelling</atitle><jtitle>Nature reviews. Molecular cell biology</jtitle><stitle>Nat Rev Mol Cell Biol</stitle><addtitle>Nat Rev Mol Cell Biol</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>18</volume><issue>10</issue><spage>610</spage><epage>621</epage><pages>610-621</pages><issn>1471-0072</issn><eissn>1471-0080</eissn><abstract>Key Points
Poly(ADP-ribose) polymerase 1 (PARP1) was the first member of the PARP family to be identified. The PARP family now comprises 18 members.
PARP1 post-translationally modifies itself and a range of other proteins that have diverse roles in different cellular processes.
The catalytic activity of PARP1 is responsible for mediating multiple DNA damage repair pathways.
PARP1 has a crucial role in the stabilization of DNA replication forks.
The role of PARP1 in remodelling chromatin overlaps with its role in DNA repair.
PARP1 inhibition is an attractive strategy for the treatment of cancers that are deficient in the repair of DNA double-strand breaks by homologous recombination.
Recent insights into the roles of poly(ADP-ribose) polymerase 1 (PARP1) in mediating various DNA repair pathways, stabilizing DNA replication and modulating chromatin structure are being exploited clinically for the treatment of DNA repair-deficient cancers.
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the maintenance of genomic stability. The inhibition of PARP1 is therefore being exploited clinically for the treatment of various cancers, which include DNA repair-deficient ovarian, breast and prostate cancers. Understanding the role of PARP1 in maintaining genome integrity is not only important for the design of novel chemotherapeutic agents, but is also crucial for gaining insights into the mechanisms of chemoresistance in cancer cells. In this Review, we discuss the roles of PARP1 in mediating various aspects of DNA metabolism, such as single-strand break repair, nucleotide excision repair, double-strand break repair and the stabilization of replication forks, and in modulating chromatin structure.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28676700</pmid><doi>10.1038/nrm.2017.53</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/337/1427/2566 631/337/151 631/67/1059/99 Adenosine diphosphate Animals Biochemistry Cancer Cancer Research Care and treatment Cell Biology Chemoresistance Chemotherapy Chromatin Chromatin Assembly and Disassembly Chromatin remodeling Deoxyribonucleic acid Developmental Biology DNA DNA Damage DNA Repair DNA Replication Double-strand break repair Genetic recombination Genomes Health aspects Humans Innovations Integrity Life Sciences Metabolism Molecular targeted therapy Nucleotide excision repair Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) Poly(ADP-ribose) polymerase Properties Prostate Prostate cancer Repair Replication forks review-article Ribose Stem Cells Transferases |
| title | The multifaceted roles of PARP1 in DNA repair and chromatin remodelling |
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